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21 results

  1. SOCIAL QUESTIONS|health|pharmaceutical industry

    #619198

    IATE #1106130
    meitibileacht an chéad aistir Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    """first-pass""-Metabolismus"
    de
    first-pass metabolism
    en
    Definition "metabolism1 of an orally taken drug or substance taking place between its site of administration, during absorption2, and before it reaches the systemic circulation1 metabolism [ IATE:3529051 ]2 absorption [ IATE:3544125 ]" Reference "COM-Terminology Coordination, based on:Pond SM, Tozer TN. First-pass elimination. Basic concepts and clinical consequences. Clin Pharmacokinet. 1984 Jan-Feb;9(1):1-25, http://www.ncbi.nlm.nih.gov/pubmed/6362950 [25.8.2014]"
    Comment The liver is usually assumed to be the major site of first-pass metabolism of a drug administered orally, but other potential sites are the gastrointestinal tract, blood, vascular endothelium, lungs, and the arm from which venous samples are taken.For some drugs, extensive first-pass metabolism precludes their use per os.
    métabolisme au premier passage
    fr