Gaois

This is a static copy of data that is exported from IATE on an occasional basis. It should not be assumed that information provided about an entry here will always correspond to the current version of the entry in IATE. That current version can be checked by clicking on the link on the upper right hand side of each entry. More information »

2 results

  1. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664661

    IATE #3592538
    teicníc núicléáise méire since Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    teicníc ZFN Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    zinc finger nuclease technique | ZFN technique | ZFN-1 | ZFN-2 | ZFN-3
    en
    Definition "gene modification technique using zinc finger nuclease" Reference "COM-Terminology Coordination, based on: EFSA Panel on Genetically modified organisms (GMO); 'Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function' (26.1.2021). EFSA Journal 2012;10(10):2943. [31 pp.] doi:10.2903/j.efsa.2012.2943. Available online: www.efsa.europa.eu/efsajournal"
    Comment "So far there are three different techniques. For more information, see: EFSA Panel on Genetically modified organisms (GMO); 'Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function' (26.1.2021). EFSA Journal 2012;10(10):2943. [31 pp.] doi:10.2903/j.efsa.2012.2943. Available online: www.efsa.europa.eu/efsajournal"
  2. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664352

    IATE #3591832
    núicléáis méire since Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    zinc finger nuclease | ZFN
    en
    Definition any of a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations Reference "COM-Terminology Coordination, based on: Merck. What Is ZFN Technology? (16.11.2020)"
    Comment Each Zinc Finger Nuclease (ZFN) consists of two functional domains: a.) A DNA-binding domain comprised of a chain of two-finger modules, each recognizing a unique hexamer (6 bp) sequence of DNA. Two-finger modules are stitched together to form a Zinc Finger Protein, each with specificity of ≥ 24 bp. b.) A DNA-cleaving domain comprised of the nuclease domain of Fok I. When the DNA-binding and DNA-cleaving domains are fused together, a highly-specific pair of 'genomic scissors' are created.