PRODUCTION, TECHNOLOGY AND RESEARCH|research and intellectual property|research · SOCIAL QUESTIONS|health|medical science
- modh ATC Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- modh aicmithe géarthocsaineachta Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- Acute-toxic-Class-Methode | ATC | Akut-Toxische Klassenmethode | Acute Toxic Class
- de
- Definition vom Bundesinstitut für Risikobewertung (BfR), Deutschland, als Ersatz der LD50-Methode entwickelte Methode zur Prüfung von Substanzen auf ihre akute orale Giftigkeit Reference Wikipedia, s. v. „Acute Toxic Class“, https://de.wikipedia.org/wiki/Acute_Toxic_Class (30.5.2017)
- ATC method | acute toxic class method
- en
- Definition a stepwise procedure with the use of three animals of a single sex per step. Depending on the mortality and/or the moribund status of the animals, on average two to four steps may be necessary to allow judgement on the acute toxicity of the test substance Reference Council Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) CELEX:32008R0440/EN
- Comment This procedure is reproducible, uses very few animals and is able to rank substances in a similar manner to the other acute toxicity testing methods. The acute toxic class method is based on biometric evaluations ( IATE:3516015 ) with fixed doses, adequately separated to enable a substance to be ranked for classification purposes and hazard assessment. The method as adopted in 1996 was extensively validated in vivo against LD50 data obtained from the literature, both nationally and internationally.