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34 toradh

  1. SCIENCE|natural and applied sciences|life sciences|biology

    #564975

    IATE #1684624
    gabhdóir Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Rezeptor
    de
    receptor
    en
    Sainmhíniú macromolecule in the membrane or inside the cell that specifically (chemically) binds a ligand (drug) Tagairt COM-EN, based on:The Journal of the International Federation of Clinical Chemistry and Laboratory Medicines (EJIFCC), 2008 Apr; 19(1): 48-53 > Pharmacogenetics of Drug Receptors (28.4.2020)
    Nóta Receptor theory is the backbone of pharmacology. The principles of receptor function have provided mechanistic explanations of great utility in pharmacology and therapeutics for understanding drug properties such as specificity, potency, and efficacy.Reference: Allan B. Okey. An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI. (28.4.2020) Toxicol. Sci. (2007) 98 (1): 5-38.
    récepteur
    fr
    Sainmhíniú au niveau cellulaire, ce sont des molécules protéiques situées sur la membrane ou dans la cellule et agissent au niveau du noyau, capables d'accueillir des molécules endogènes ou des médicaments spécifiques Tagairt FRM,Gloss.textes scientifiques,mars 1998
  3. SOCIAL QUESTIONS|health|pharmaceutical industry

    #569959

    IATE #2224770
    blocálaí gabhdóirí angaitheannaine Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    ARB | Angiotensin II-Antagonist | Angiotensin-Rezeptor-Blocker | Angiotensin II-Hemmer
    de
    Sainmhíniú Medikament zur Hemmung der Wirkung des Hormons Angiotensin II Tagairt eesom, http://www.eesom.com/de/anginapectoris.php (01.06.2007)
    Nóta wirkt als spezifischer Hemmstoff am Subtyp 1 des Angiotensin-II-Rezeptors und senkt den Gefäßwiderstand im Körper
    angiotensin receptor antagonist | ARA | angiotensin II type 1 receptor antagonist | angiotensin II type 1 receptor blocker | angiotensin-receptor blocker | AII inhibitor | angiotensin II inhibitor | ARB
    en
    Sainmhíniú hypertension drugs that prevent angiotensin II from binding with its receptors on the surface of the cells Tagairt COM/DGT-Terminology Coordination
    Nóta the hypertension drugs that prevent the conversion of angiotensin I to angiotensin II are called "angiotensin-converting enzyme inhibitors" (ACE inhibitors or ACEI) [ IATE:1040702 ]. For more information, see also: Angiotensin II Receptor Blockers http://www.ti.ubc.ca/pages/letter28.htm [31.5.2007]
    bloqueur des récepteurs AT1 de l'angiotensine II | bloqueur des récepteurs de l'angiotensine II | ARA II | ARAII | antagoniste des récepteurs AT1 de l'angiotensine II | ARA-II | ARA | antagoniste des récepteurs de l'angiotensine II
    fr
    Sainmhíniú médicament pour le traitement de l'hypertension et de l'insuffisance cardiaque congestive qui bloque la fixation de l'angiotensine sur ses récepteurs (AT1 , AT2) Tagairt Sur la base de: Facultés universitaires Notre-Dame de la Paix, Namur, http://www.fundp.ac.be/recherche/projets/page_view/94273108/ [1.6.2007] et amc.ca, Racine N., White M. Le rôle des bloqueurs des récepteursde AT-II dans l'insuffisance cardiaque congestive, http://www.cma.ca/index.cfm/ci_id/24826/la_id/2.htm [1.6.2007]
    Nóta il existe deux sortes de récepteurs de l'angiotensine, les récepteurs AT1 et les récepteurs AT2. La plupart des médicaments bloquent les récepteurs AT1. A ne pas confondre avec les médicaments qui inhibent la production de l'angiotensine II [ IATE:1040702 ]
  4. SCIENCE|natural and applied sciences|life sciences|biology · SOCIAL QUESTIONS|health|medical science

    #596881

    IATE #3589292
    fearann nasctha gabhdóirí Tagairt Faofa ag an gCoiste Téarmaíochta, www.tearma.ie ;Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    rezeptorbindende Domäne
    de
    RBD | RBDs | receptor-binding domain
    en
    Sainmhíniú regions of several hundred amino acids that can fold independently and that are sufficient for binding to the host cell receptor Tagairt COM-EN, based on: N. Promkuntod, R.E.W. van Eijndhoven, G. de Vrieze, A. Gröne, M.H. Verheije. 'Mapping of the receptor-binding domain and amino acids critical for attachment in the spike protein of avian coronavirus infectious bronchitis virus' (23.4.2020). Virology Volume 448, 5 January 2014, Pages 26-32
    domaine de liaison au récepteur
    fr
  5. SCIENCE|natural and applied sciences|life sciences|pharmacology

    #552822

    IATE #1323258
    freasaitheach gabhdóra Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    antagonist | receptor antagonist
    en
    Sainmhíniú drug that reduces the action of another drug, generally an agonist Tagairt RICHARD R. NEUBIG, MICHAEL SPEDDING, TERRY KENAKIN, AND ARTHUR CHRISTOPOULOS. 'International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology' (4.2.2022). PHARMACOLOGICAL REVIEWS. Vol. 55, No. 4. The American Society for Pharmacology and Experimental Therapeutics
    Nóta Can be competitive or non-competitive, each of which can be reversible or irreversible. A competitive antagonist binds to the same site as the agonist but does not activate it, thus blocks the agonist’s action. A non-competitive antagonist binds to an allosteric (non-agonist) site on the receptor to prevent activation of the receptor. A reversible antagonist binds non-covalently to the receptor, therefore can be “washed out”. An irreversible antagonist binds covalently to the receptor and cannot be displaced by either competing ligands or washing.
  6. SOCIAL QUESTIONS|health|medical science

    #544209

    IATE #1073479
    gabhdóir aicéitiolchoilín Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    cholinergischer Neurotransmitter-spezifischer Rezeptor | cholinergischer Rezeptor
    de
    Sainmhíniú Rezeptor der acetylcholin-ausschüttend wirkt. Tagairt Buddecke p.508
    AChR | cholinergic receptor | acetylcholine receptor | cholinoceptor
    en
    Sainmhíniú any of the sites in effector cells or at synapses through which acetylcholine exerts its action Tagairt 'cholinergic receptor' (29.4.2020), The Free Dictionary.
    Nóta They are of two types: muscarinic and nicotinic cholinergic receptors.
    récepteur cholinergique | récepteur de l'acétylcholine
    fr
  7. SOCIAL QUESTIONS|health|pharmaceutical industry

    #544208

    IATE #1073476
    gabhdóir aidréineirgeach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    adrenerger Rezeptor
    de
    adrenergic receptor | adrenoreceptor
    en
    Sainmhíniú class of receptors that are targets of the catecholamines [ IATE:1506050 ], especially norepinephrine (noradrenaline) and epinephrine (adrenaline) Tagairt COM-EN, based on:Adrenergic receptor. http://en.wikipedia.org/wiki/Adrenergic_receptor [11.5.2012]
    Nóta Although dopamine is a catecholamine, its receptors are in a different category.There are two main groups of adrenergic receptors, α and β, with several subtypes. For more information, see: Adrenergic receptor. http://en.wikipedia.org/wiki/Adrenergic_receptor [12.6.2012] & David Goodsell & RCSB Protein Data Bank. Adrenergic Receptors http://www.rcsb.org/pdb/101/motm.do?momID=100 [12.6.2012]
    adrénorécepteur | récepteur adrénergique
    fr
  8. SOCIAL QUESTIONS|health|pharmaceutical industry

    #582134

    IATE #3543191
    gabhdóir aidréineirgeach alfa-2 Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    a2-adrenoceptor | α-2 adrenoreceptor | alpha-2 adrenergic receptor | α2-adrenoceptor | α2-adrenergic receptor
    en
    Sainmhíniú type of adrenergic receptor [ IATE:1073476 ] which is typically sited presynaptically, but can also occur postsynaptically Tagairt COM-EN, based on:Adrenoceptor Online. Introduction to α-Adrenoceptors http://www.adrenoceptor.com/alphaintro.htm [3.5.2012]
  9. SCIENCE|natural and applied sciences|life sciences|biology

    #543414

    IATE #1052552
    gabhdóir cionáise tirisín Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    tyrosine kinase receptor | receptor tyrosine kinase | RTK | RTKs | TKR | TRKs
    en
    Sainmhíniú cell surface receptor that also has a tyrosine kinase activity Tagairt Kevin Ahern & Indira Rajagopal, '8.5: Receptor Tyrosine Kinases (RTKs)' (16.11.2020), Biology LibreTexts
    Nóta The signal binding domain of the receptor tyrosine kinase is on the cell surface, while the tyrosine kinase enzymatic activity resides in the cytoplasmic part of the protein (see figure above). A transmembrane alpha helix connects these two regions of the receptor.
  10. SCIENCE|natural and applied sciences|life sciences · SCIENCE|natural and applied sciences|life sciences|biology · SCIENCE|natural and applied sciences|life sciences|pharmacology

    #528266

    IATE #286712
    gabhdóir cúpláilte próitéine G Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    G protein-coupled receptor | seven-spanning receptor | GPCR | G-protein coupled receptor | G protein receptor
    en
    Sainmhíniú any in one of the largest subset of receptors, including receptors for many hormones and slow neurotransmitters, and more specificallya membrane receptor that interacts with G proteins in the plasma membrane Tagairt COM-Terminology Coordination, based on:1) J.E. Campbell, D. Cohall. 'Chapter 26 - Pharmacodynamics — A Pharmacognosy Perspective. Pharmacognosy Fundamentals' (18.2.2020), Applications and Strategies 2017, Pages 513-525. Academic Press2) 'GPCR' (18.2.2020). Scitable by Nature Education
    Nóta When an external signaling molecule binds to a GPCR, it causes a conformational change in the GPCR. This change then triggers the interaction between the GPCR and a nearby G protein.
    RCPG | récepteur couplé à la protéine G
    fr
  11. SOCIAL QUESTIONS|health|pharmaceutical industry

    #527790

    IATE #202511
    gabhdóir dopaimín Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Dopamin-Rezeptor
    de
    dopamine receptor
    en
    Sainmhíniú receptor [ IATE:1684624 ] whose primary endogenous ligand [ IATE:1463918 ] is the neurotransmitter [ IATE:1073475 ] dopamine [ IATE:1894513 ] Tagairt COM-EN, based on: Philip G. Strange. DOPAMINE RECEPTORS. Tocris Cookson Ltd http://web.unife.it/sezione/fisiologia/DA%20Pharmacology/Literature/dopreview.pdf [25.5.2012]
    récepteur de la dopamine
    fr
  12. SCIENCE|natural and applied sciences|life sciences|biology

    #598405

    IATE #3592952
    gabhdóir ianchainéil Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    ion channel receptor | channel protein | ion channel
    en
    Sainmhíniú protein located in the plasma membrane and that arranges itself so that it forms a passageway or pore [ IATE:1149329/EN ] extending from one side of the membrane to the other Tagairt COM-Terminology Coordination, based on: 'Ion Channel' (23.2.2021). Scitable by Nature Education
    Nóta Both the amino acids that line a channel and the physical width of the channel determine which ions are able to wiggle through from the cell exterior to its interior, and vice versa
  13. SCIENCE|natural and applied sciences|life sciences

    #593283

    IATE #3577885
    gabhdóir ianchainéil lioganngheataithe Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    chemically gated ion channel | ligand-gated ion channel receptor | ligand-gated ion channel | ionotropic receptor
    en
    Sainmhíniú ion channel receptor which has to be bound by a ligand (i.e. a molecule that binds another specific molecule, in some cases, delivering a signal in the process) or a signal molecule for the channel to open its pores [ IATE:1149329/EN ] Tagairt COM-Terminology Coordination, based on: 1) J.E. Campbell, D. Cohall. 'Chapter 26 - Pharmacodynamics — A Pharmacognosy Perspective. Pharmacognosy Fundamentals'(18.2.2020), Applications and Strategies 2017, Pages 513-525. Academic Press2) Lisa Bartee, Walter Shriner, and Catherine Creech. Principles of Biology: Biology 211, 212, and 213. 'Types of Receptors' (18.2.2020)
    Nóta Such specific ligands or signal molecules are hormones, neurotransmitters, or local hormones. Such channels are primarily responsible for impulse initiation = initial depolarization of an excitable cell such as neurons, muscle cells, and gland cells; they can contribute to either depolarization, repolarization or hyperpolarization of a cell, depending on circumstances.
  14. SCIENCE|natural and applied sciences|life sciences|biology

    #543390

    IATE #1049358
    gabhdóir incheallach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir inmheánach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir cíteaplasmach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    intracellular receptor | cytoplasmic receptor | internal receptor
    en
    Sainmhíniú receptor found in the cytoplasm of the cell which responds to hydrophobic ligand molecules that are able to travel across the plasma membrane Tagairt Lisa Bartee, Walter Shriner and Catherine Creech, 'Types of Receptors' (22.3.2021), In: Lisa Bartee, Walter Shriner and Catherine Creech, Principles of Biology, Open Oregon Educational Resources
  15. SOCIAL QUESTIONS|health|pharmaceutical industry

    #550809

    IATE #1231575
    KOP Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir k-ópóideach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    kappa opioid receptor | κ receptor | kappa receptor | KOP | κ-opioid receptor
    en
    Sainmhíniú class of opioid receptor [ IATE:1666898 ] mediating analgesia (pain relief), sedation, miosis (constricted pupils) and diuresis Tagairt COM-EN, based on:EMBL-EBI. IPR000452 Kappa opioid receptor http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000452 [16.5.2012]
    Nóta Dynorphin is the most potent endogenous ligand.The receptors were named using the first letter of the first ligand that was found to bind to them. Morphine was the first chemical shown to bind to mu receptors.
  16. SOCIAL QUESTIONS|health|pharmaceutical industry

    #527789

    IATE #202505
    gabhdóir mu-ópóideach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    MU-Rezeptor
    de
    MOP | mu receptor | μ-receptor | μ-opioid receptor | mu-opioid receptor
    en
    Sainmhíniú class of opioid receptors [ IATE:1666898 ] mediating analgesia (pain relief), hypothermia, respiratory depression , miosis (constricted pupils), bradycardia [ IATE:1499659 ], nausea, euphoria and physical dependence Tagairt COM-EN, based on:EMBL-EBI. IPR000105 Mu opioid receptor http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000105 [16.5.2012]
    Nóta Beta-endorphin is the most potent endogenous ligand [ IATE:1463918 ].The receptors were named using the first letter of the first ligand that was found to bind to them. Morphine was the first chemical shown to bind to mu receptors. The first letter of the drug morphine is m, but in biochemistry there is a tendency to use Greek letters, thus turning the m to μ.
    récepteur 'mu'
    fr
  17. SOCIAL QUESTIONS|health|pharmaceutical industry

    #582218

    IATE #3543832
    gabhdóir muscairineach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    muscarinic receptor | muscarinic acetylcholine receptor
    en
    Sainmhíniú type of cholinergic receptor [ IATE:1073479 ] Tagairt COM-EN, based on:Rebecca L. Kow& Neil M. Nathanson. Structural biology: Muscarinic receptors become crystal clear. Nature 482, 480–481 (23 February 2012) http://www.nature.com/nature/journal/v482/n7386/full/482480a.html [23.5.2012]
  18. SCIENCE|natural and applied sciences|life sciences|biology

    #566190

    IATE #1757859
    gabhdóir NMDA Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    NMDA-Rezeptor
    de
    Sainmhíniú der biophysikalische Prozeß, der zur Ausbildung von LTP führt, ist formal der Hebb-Regel sehr ähnlich. Eine wichtige Rolle bei der Veränderung der Synapsenstärke spielt der NMDA (N-methyl-D-aspartat)-Rezeptor. Dieser Rezeptor erlaubt einen Einstrom von Calcium in die Synapse nur dann, wenn sowohl die präsynaptische als auch die postsynaptische Nervenzelle gleichzeitig aktiv sind. Dieser Einstrom setzt dann einen Prozeß in Gang, der zur Verstärkung der Synapse führt Tagairt McNaughton,1987
    NMDAR | NMDA receptor | NMDARs
    en
    Sainmhíniú glutamate-gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms Tagairt Blanke ML, VanDongen AMJ. 'Activation Mechanisms of the NMDA Receptor' (15.4.2021). In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 13.
    Nóta They are critical for the development of the central nervous system (CNS), generation of rhythms for breathing and locomotion, and the processes underlying learning, memory, and neuroplasticity. Consequently, abnormal expression levels and altered NMDAR function have been implicated in numerous neurological disorders and pathological conditions.
    récepteur NMDA | récepteur du N-méthyl D-aspartate
    fr
    Sainmhíniú processus biophysique qui gère la potentialisation à long terme; le récepteur fixe un acide aminé synthétique, le N-méthyl D-aspartate; lorsque les cellules présynaptiques et postsynaptiques sont simultanément actives, des ions calcium entrent dans les cellules Tagairt Pour la Science,11.92,77
  19. SCIENCE|natural and applied sciences|life sciences · SCIENCE|natural and applied sciences|life sciences|biology

    #568756

    IATE #2101603
    gabhdóir núicléach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir núicléach hormón Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    nuclear receptor | nuclear hormone receptor
    en
    Sainmhíniú any of a group of transcription factors that, through ligand-binding, act as sensors to changes in nutritional, environmental, developmental, pathophysiologic, and endocrine conditions and drive adaptive responses via gene regulation Tagairt Donato F. Romagnolo, Janos Zempleni, Ornella I. Selmin, 'Nuclear Receptors and Epigenetic Regulation: Opportunities for Nutritional Targeting and Disease Prevention' (18.2.2020), Advances in Nutrition, Volume 5, Issue 4, July 2014, Pages 373–385
    Nóta They include:- type I nuclear receptors, also called steroid receptors- type II nonsteroid nuclear receptors- orphan nuclear receptors
    récepteur nucléaire des hormones
    fr
  20. SOCIAL QUESTIONS|health|pharmaceutical industry

    #548072

    IATE #1150092
    gabhdóir ópóideach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Opiat-Rezeptor | Rezeptor für Opiate
    de
    receptors | opioid receptor
    en
    Sainmhíniú receptor with opioids [ IATE:3529317 ] as ligands Tagairt Wikipedia. Opioid receptor http://en.wikipedia.org/wiki/Opioid_receptor [16.5.2012]
    Nóta There are three principal classes of opioid receptors, μ, κ, δ (mu, kappa, and delta), although up to seventeen have been reported, and include the ε, ι, λ, and ζ (Epsilon, Iota, Lambda and Zeta) receptors.
    récepteur opioïde
    fr
    Sainmhíniú récepteur cérébral des opiacés Tagairt Pour la Science,mai 1991