Gaois

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  1. SOCIAL QUESTIONS|health|pharmaceutical industry · SCIENCE|natural and applied sciences|life sciences|pharmacology

    #677461

    IATE #1106130
    meitibileacht an chéad aistir Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    first-pass metabolism | first-pass effect
    en
    Definition "pharmacological phenomenon taking place between the site of administration of a medicinal product, during absorption, and before it reaches the systemic circulation in which the medication undergoes metabolism at a specific location in the body resulting in a decrease of the active drug's concentration upon reaching systemic circulation or its site of action" Reference "COM-Terminology Coordination, based on:- Pond SM, Tozer TN. 'First-pass elimination. Basic concepts and clinical consequences' (27.3.2024). Clin Pharmacokinet. 1984 Jan-Feb;9(1):1-25- Herman TF, Santos C. 'First-Pass Effect' (27.3.2024). [Updated 2023 Nov 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. "
    Comment The first-pass effect is often associated with the liver, a major site of drug metabolism. However, the first-pass effect can also occur in the body's lungs, vasculature, gastrointestinal tract, and other metabolically active tissues.For some drugs, extensive first-pass metabolism precludes their use per os.