SAINMHÍNIÚ an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry TAGAIRT H. Hayen, M.M. Alvarez-Grima, S.C. Debnath, J.W.M. Noordermeer,and U. Karst, Analytical Chemistry 76, 1063 (2004) http://www.mechlab.utwente.nl/physicalanalysis/chemical/Liquid_Chromatograph.whlink/ [10.7.2009]

NÓTA LC-MS is a technique used for many applications which has very high sensitivity and specificity. Generally its application is oriented towards the specific detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture).

NÓTA The major advantage MS has is the use of tandem MS-MS. The detector may be programmed to select certain ions to fragment. The process is essentially a selection technique, but is in fact more complex. The measured quantity is the sum of molecule fragments chosen by the operator. As long as there are no interferences or ion suppression, the LC separation can be quite quick. It is common now to have analysis times of 1 minute or less by MS-MS detection, compared to over 10 mins with UV detection