AGRICULTURE, FORESTRY AND FISHERIES|agricultural activity|animal health
- vacsaín bheo Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- Context 'I gcásanna vacsaíní beo i gcomhair zúnóisí de réir bhrí Threoir 2003/99/CE ó Pharlaimint na hEorpa agus ón gComhairle atá le húsáid i gcomhair bia-ainmhithe, is gá na staidéir sin a chur san áireamh, go háirithe cé chomh fada a mhaireann an t-orgánach ag an mball insteallta.' Reference "Rialachán (AE) 2019/6 maidir le táirgí íocshláinte tréidliachta agus lena n-aisghairtear Treoir 2001/82/CE, CELEX:32019R0006/GA"
- live vaccine | live-strain vaccine
- en
- Definition any vaccine that does not contain an inactivated (killed) product, although it is recognised that in the case of viruses they cannot be considered truly alive Reference "COM-Terminology Coordination, based on: World Organisation for Animal Health (OIE). 'Chapter 1.1.8. Principles of Veterinary Vaccine Production' (20.5.2019). Terrestrial Manual 2018."
- Comment Vaccines may be prepared as live or inactivated (killed) products. Some live vaccines are prepared from low virulence, mild, field isolates of a disease-causing agent that have been found to be safe and effective when administered by an unnatural route or under other conditions where exposure to the microorganism will immunise rather than cause disease. Other live vaccines are prepared from isolates of disease-causing agents that have been modified by passage through laboratory animals, culture media, cell cultures, or avian embryos to select a variant of reduced virulence. The development of recombinant DNA (rDNA) procedures has provided some unique opportunities for vaccine production. Modified live vaccines may now be specifically produced by deletion of virulence-related genes from a microorganism. Others are produced by the insertion of genes that code for specific immunising antigens from a disease-causing microorganism into a nonvirulent vector microorganism. Nucleic-acid-mediated vaccines containing plasmid DNA have been developed. The DNA is usually in plasmid form and codes for immunising antigens from disease-causing microorganisms. Killed products may contain: 1) Cultures of microorganisms that have been inactivated by chemical or physical means; 2) Inactivated toxins; or 3) Subunits (antigenic parts of microorganisms) that have been extracted from cultures or that have been produced through rDNA procedures.