SCIENCE|natural and applied sciences|life sciences|biology
- spladhsáil mhalartach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- spladhsáil mhalartach mRNA Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- alternative splicing | alternative mRNA splicing | alternative pre-mRNA splicing
- en
- Definition "mechanism through which particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene by selecting different combinations of splice sites within a pre-mRNA" Reference "COM-Terminology Coordination, based on: - Wikipedia > Alternative splicing (27.4.2021)- D.S. Greenberg, H.Soreq., 'Alternative Splicing' (18.11.2020), In: Reference Module in Biomedical Sciences Brenner's Encyclopedia of Genetics (Second Edition) 2013, Pages 97-98"
- Comment It differs from constitutive splicing in that alternative exons might or might not be included, and there may be exon skipping, intron retention, alternative 5′ and 3′ splice sites and mutually exclusive exons, leading to the generation of potentially hundreds of proteins from a single mRNA. In some instances, multiple mRNAs are generated that all lead to the translation of the same protein product, for example brain-derived neurotrophic factor (BDNF).
- épissage différentiel | épissage alternatif de l'ARN messager | épissage alternatif de l'ARNm
- fr
- Definition existence de plusieurs schémas d'épissage d'un transcrit primaire aboutissant à la formation de différents RNA messagers, et pouvant donner lieu à la synthèse de plusieurs protéines différentes Reference Schorderet,D.,Gloss.génétique,Division de génétique médicale,CHUV,Lausanne,1993