Gaois

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  1. SOCIAL QUESTIONS|health|pharmaceutical industry

    #677459

    IATE #1106085
    ceangal plasmaphróitéine Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Context 'Déanfar cur síos ar dháileadh an táirge íocshláinte tréidliachta sa spriocainmhí. Breithneofar an fhéidearthacht go dtarlódh ceangal plasmaphróitéine nó gluaiseacht isteach i mbainne nó in uibheacha agus carnadh comhdhúile lipifileacha.' Reference "Rialachán (AE) 2019/6 maidir le táirgí íocshláinte tréidliachta agus lena n-aisghairtear Treoir 2001/82/CE, CELEX:32019R0006/GA"
    ceangal próitéine Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Context 'Déanfar cur síos ar dháileadh an táirge íocshláinte tréidliachta sa spriocainmhí. Breithneofar an fhéidearthacht go dtarlódh ceangal plasmaphróitéine nó gluaiseacht isteach i mbainne nó in uibheacha agus carnadh comhdhúile lipifileacha.' Reference "Rialachán (AE) 2019/6 maidir le táirgí íocshláinte tréidliachta agus lena n-aisghairtear Treoir 2001/82/CE, CELEX:32019R0006/GA"
    plasma protein binding | protein binding
    en
    Definition interaction in which a drug binds to the proteins within blood plasma Reference "COM-Terminology Coordination, based on:Wikipedia. Plasma protein binding, http://en.wikipedia.org/wiki/Plasma_protein_binding [8.1.2014]"
    Comment A drug in blood exists in two forms: bound and unbound. Depending on a specific drug's affinity for plasma protein, a proportion of the drug may become bound to plasma proteins, with the remainder being unbound. If the protein binding is reversible, then a chemical equilibrium will exist between the bound and unbound states, such that: Protein + drug ⇌ Protein-drug complexit is the unbound fraction which exhibits pharmacologic effects. It is also the fraction that may be metabolized and/or excreted.The bound portion may act as a reservoir or depot from which the drug is slowly released as the unbound form. Since the unbound form is being metabolized and/or excreted from the body, the bound fraction will be released in order to maintain equilibrium.