Gaois

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3 results

  1. SOCIAL QUESTIONS|health|medical science

    #648728

    IATE #3543799
    imshuí néaramhatánach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    neuromuscular blockade | neuromuscular block
    en
    Definition failure in neuromuscular transmission that can be induced pharmacologically or may result from pathological disturbances at the myoneural junction Reference "Dorland's Medical Dictionary for Health Consumers. © 2007 by Saunders http://medical-dictionary.thefreedictionary.com/neuromuscular+blockade [18.5.2012]"
  2. SOCIAL QUESTIONS|health|pharmaceutical industry

    #648722

    IATE #3543791
    blocálaí néaramhatánach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    neuromuscular blocking drug | neuromuscular blocking agent | neuromuscular junction blocking agent
    en
    Definition "any drug which blocks neuromuscular transmission at the neuromuscular junction [ IATE:1232550 ] causing paralysis of the affected skeletal muscles" Reference "Wikipedia. Neuromuscular-blocking drug http://en.wikipedia.org/wiki/Neuromuscular-blocking_drug [16.5.2012]"
    Comment This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate. While there are drugs that act presynaptically (such as botulinum toxin and tetanus toxin), the clinically-relevant drugs work postsynaptically.In clinical use, neuromuscular block is used adjunctively to anesthesia to produce paralysisThese drugs fall into two groups: 1) Depolarising blocking agents 2) Non-depolarising blocking agents
  3. SOCIAL QUESTIONS|health|pharmaceutical industry

    #648723

    IATE #3543792
    oibreán bacainneach néaramhatánach neamh-dhípholarúcháin Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    non-depolarising neuromuscular blocking agent | non-depolarising NMBA
    en
    Definition "drug which is a competitive antagonist [ IATE:3531470 ] at cholinergic receptors [ IATE:1073479 ] on the motor end plate [ IATE:1540819 ], and thus it blocks neuromuscular transmission at the neuromuscular junction [ IATE:1232550 ], causing paralysis of the affected skeletal muscles, and which does not depolarise [ IATE:1509622 ] the end plate and does not produce fasciculations [ IATE:1684336 ]" Reference "COM-EN, based on:Dr Robert Grace. NEUROMUSCULAR JUNCTION BLOCKING AGENTS (NMBA’S) http://www.ciap.health.nsw.gov.au/nswtag/publications/posstats/Archives/NeuromuscularJunctionBlockingAgentsNC.pdf [16.5.2012]"