SCIENCE|natural and applied sciences|life sciences|pharmacology
- spriocphróitéin druga Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- drug-target protein | drug target protein | drug target protein type
- en
- Definition protein whose biological activity or function is activated or inhibited by a drug, resulting in a specific effect, which may be a desirable therapeutic effect or an unwanted adverse effect Reference "COM-EN, based on: - Zhan-Chao Li, et al., 'Identification of drug–target interaction from interactome network with ‘guilt-by-association’ principle and topology features' (30.9.2024), Bioinformatics, Volume 32, Issue 7, April 2016, Pages 1057–1064. - Wikipedia > Biological target (30.9.2024)"
- Comment One of the basic mechanisms of antimicrobial resistance is the alteration of the drug target (or production of a new protein target to replace the inactivated target) so the drug binds poorly and has diminished effect. Higher concentrations of drug may bind sufficiently to produce an antibacterial effect, but such levels may not always be achievable.
- protéine cible d'un médicament | protéine à cible pharmacologique
- fr
- Definition protéine dont l'activité biologique est activée ou inhibée par un médicament, ce qui peut entraîner un effet thérapeutique recherché ou un effet indésirable Reference "COM-FR d'après: - «Bioinformatics - Identification of drug–target interaction from interactome network with ‘guilt-by-association’ principle and topology features» (disponible en anglais uniquement), Zhan-Chao Li, Meng-Hua Huang, Wen-Qian Zhong, Zhi-Qing Liu, Yun Xie, Zong Dai et Xiao-Yong Zou, (1.4.2016), Volume 32, Issue 7, ISSN 1367-4803, https://academic.oup.com/bioinformatics/article/32/7/1057/1743938 [9.7.2018] - Article de Wikipédia > «Biological target», https://en.wikipedia.org/wiki/Biological_target#Drug_targets [9.7.2018]"