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  1. SCIENCE|natural and applied sciences|life sciences|pharmacology

    #687709

    IATE #3637132
    comhchoibhneas <i>in vitro-in vivo</i> Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    in vitro-in vivo correlation | IVIVC
    en
    Definition mathematical model that can help predict in vivo performance of a pharmaceutical dosage form based on its in vitro performance (drug release profiles) Reference "COM-Terminology Coordination, based on: USP. 'In Vivo In Vitro Correlation (IVIVC) (Classroom)' (22.2.2023)"
    Comment To develop an effective IVIVC, the physicochemical and biopharmaceutical properties of the drug as well as the physiological environment in the body must be taken into consideration. Key factors include drug solubility, pKa, drug permeability, octanol-water partition coefficient and pH of environment. In general, construction of an IVIVC involves three stages of mathematical manipulation: construct a functional relationship between input (in vitro dissolution) and output (in vivo dissolution); establish a structural relationship using data collected; parameterize the unknowns in the structural model. Some key mathematical relationships used in IVIVC development are presented. The establishment of an effective IVIVC has important implications in quality control and regulatory compliance.