SOCIAL QUESTIONS|health|pharmaceutical industry
- analóg núicléisíde Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- Nukleosidanalog | Nukleosid-Analogon | Nukleosidanalogon
- de
- Definition Substanzen, die natürlichen Nukleosiden ähneln, wie z. B. die nukleosidischen Reverse-Transkriptase-Inhibitoren (NRTI), und als Arzneistoffe vor allem in der antiviralen Therapie angewendet werden, z.B. gegen HIV, HBV und HBC Reference "DocCheckFlexikon, s. v. „Nukleosidanalogon“, http://flexikon.doccheck.com/de/Nukleosidanalogon (24.10.2017)"
- nucleoside analog | nucleoside analogue
- en
- Definition synthetic molecule that resembles a naturally occuring nucleoside, but that lacks a bond site needed to link it to an adjacent nucleotide Reference "'nucleoside analog' (19.10.2021). Hedgehog Signaling Glossary"
- Comment Nucleoside analogues (NA) constitute an important class of antimetabolites used in the treatment of hematological malignancies and, more recently, in solid tumors. These therapeutic compounds mimic physiological nucleosides in terms of uptake and metabolism and are incorporated into newly synthesized DNA resulting in synthesis inhibition and chain termination. Some of these drugs also inhibit key enzymes involved in the generation of the purine and pyrimidine nucleotides and RNA synthesis, and directly activate the caspase cascade. All of these effects may lead to cell death.
- analogue nucléosidique | analogue de nucléoside
- fr
- Definition composé synthétique similaire à l'un des nucléotides présents dans l'ADN ou l'ARN d'un virus ou d'un rétrovirus Reference Act Up-Paris,Gloss.sida,janvier 1998