Gaois

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  1. SOCIAL QUESTIONS|health|medical science · PRODUCTION, TECHNOLOGY AND RESEARCH|research and intellectual property|research

    #616811

    IATE #1030541
    nós imeachta na ndáileog socraithe Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    nós imeachta na dáileoige socraithe Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ie Faomhadh an téarma seo mar chuid de Thionscadal Lex"
    ga
    Fest-Dosis-Methode | Festdosis-Methode | Fixed-Dose-Verfahren | Festdosismethode
    de
    FDP | fixed dose procedure
    en
    Definition method for assessing a substance's acute oral toxicity during which the test substance is given at one of the four fixed-dose levels (5, 50, 500, and 2000 mg/kg) to five male and five female rats. The objective is to identify a dose that produces clear signs of toxicity but no mortality. Depending on the results of the first test, either no further testing is needed or a higher or lower dose is tested: If mortality occurs, retesting at a lower dose level is necessary (except if the original dose chosen is 5 mg/kg). If no signs of toxicity occur at the initial dose, it is necessary to retest at a higher dose level. The results are thus interpreted in relation to animal survival and evident toxicity Reference "COM-EN, based on:Wikipedia. Fixed Dose Procedure http://en.wikipedia.org/wiki/Fixed_Dose_Procedure [13.7.2012]"
    Comment proposed by the British Toxicology Society (1984) as an alternative to assessment of acute oral toxicity via estimation of the LD50