Gaois

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  1. SCIENCE|natural and applied sciences|life sciences|pharmacology

    #649465

    IATE #3546054
    imoibriú comhchuingiúcháin Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    conjugation | conjugation reaction | phase II reaction | phase II metabolism | phase 2 metabolism
    en
    Definition attachment of an ionised group to a xenobiotic to make it more water soluble and facilitate its excretion Reference "COM-Terminology Coordination, based on: University of Nottingham. 'Phase 2 Metabolism' (7.2.2023)"
    Comment Conjugation reactions usually involve metabolite activation by a high–energy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product.