PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology
- próitéin Cas ion-núicléáis-uireasach Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ieFaomhadh an téarma seo mar chuid de Thionscadal Lex"
- ga
- dCas Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ieFaomhadh an téarma seo mar chuid de Thionscadal Lex"
- ga
- dCas | endonuclease-deficient Cas protein | nuclease-dead Cas | dead Cas
- en
- Definition "Cas protein with no nuclease [ IATE:1478919/EN ] activity but which retains its other functions" Reference "COM-Terminology Coordination, based on: - Regina Mirgayazova, Raniya Khadiullina, Vitaly Chasov, Rimma Mingaleeva, Regina Miftakhova, Albert Rizvanov and Emil Bulatov. 'Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?' (15.1.2021) Genes 2020, 11(6), 704- Yang et al., 2019, 'Dynamic Imaging of RNA in LivingCells by CRISPR-Cas13 Systems' (15.1.2021). Molecular Cell 76, 981–997 December 19, 2019. 2019 Elsevier Inc."
- Comment The dCas9 is a non-functional nuclease that still retains the ability to bind DNA in an sgRNA-mediated manner, while dCas13s still allow robust real-time imaging and tracking of RNAs in live cells