Gaois

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  1. SCIENCE|natural and applied sciences|life sciences

    #653099

    IATE #3562571
    sintéis trasloit Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    TLS Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    translesion synthesis | TLS | translesion DNA synthesis
    en
    Definition DNA damage tolerance process in which specialised DNA polymerases replicate across from DNA lesions Reference "COM-Terminology Coordination, based on:Lauren S. Waters, Brenda K. Minesinger, Mary Ellen Wiltrout, Sanjay D'Souza, Rachel V. Woodruff, and Graham C. Walker. Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance. Microbiol Mol Biol Rev. Mar 2009; 73(1): 134–154, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650891/ [17.10.2014]"
    Comment TLS aids in resistance to DNA damage, presumably by restarting stalled replication forks or filling in gaps that remain in the genome due to the presence of DNA lesions. One consequence of this process is the potential risk of introducing mutations