Gaois

This is a static copy of data that is exported from IATE on an occasional basis. It should not be assumed that information provided about an entry here will always correspond to the current version of the entry in IATE. That current version can be checked by clicking on the link on the upper right hand side of each entry. More information »

4 results

  1. SCIENCE|natural and applied sciences|life sciences|pharmacology

    #687709

    IATE #3637132
    comhchoibhneas <i>in vitro-in vivo</i> Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    in vitro-in vivo correlation | IVIVC
    en
    Definition mathematical model that can help predict in vivo performance of a pharmaceutical dosage form based on its in vitro performance (drug release profiles) Reference "COM-Terminology Coordination, based on: USP. 'In Vivo In Vitro Correlation (IVIVC) (Classroom)' (22.2.2023)"
    Comment To develop an effective IVIVC, the physicochemical and biopharmaceutical properties of the drug as well as the physiological environment in the body must be taken into consideration. Key factors include drug solubility, pKa, drug permeability, octanol-water partition coefficient and pH of environment. In general, construction of an IVIVC involves three stages of mathematical manipulation: construct a functional relationship between input (in vitro dissolution) and output (in vivo dissolution); establish a structural relationship using data collected; parameterize the unknowns in the structural model. Some key mathematical relationships used in IVIVC development are presented. The establishment of an effective IVIVC has important implications in quality control and regulatory compliance.
  2. SOCIAL QUESTIONS|health|medical science|medical research · SOCIAL QUESTIONS|health|medical science

    #688740

    IATE #3642146
    córas samhla <i>in vivo</i> Reference "Cinneadh Cur Chun Feidhme (AE) 2023/2865 lena mbunaítear an Cuibhreannas don Bhonneagar Taighde Eorpach INFRAFRONTIER (INFRAFRONTIER ERIC) (a bhfuil fógra tugtha ina leith faoi dhoiciméad C (2023) 8865), CELEX:32023D2865/GA Faomhadh an téarma seo mar chuid de Thionscadal Lex"
    ga
    In-vivo-Modellsystem
    de
    in vivo model system
    en
    Definition living biological system (i.e. animal or cells) used in the lab for biomedical research Reference "COM-Terminology Coordination, based on:- Nature > subjects > 'disease model' (15.11.2023)- Elaine A. Ostrander, Ph.D. 'Animal Model' (15.11.2023). National Human Genome Research Institute"
  3. SOCIAL QUESTIONS|health|pharmaceutical industry

    #688268

    IATE #3640007
    tástáil neamhdhaonna <i>in vivo</i> Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    non-human in vivo test
    en
    Definition test not performed on humans but performed in vivo Reference European Commission. DG SANTE. Correspondence dated 22.5.2023
    Comment i.e. such a test may include simple and complex human cell-based assays, microphysiological systems including organ-on-chip, computer modelling, other non-human or human biology-based test methods, and animal-based tests
  4. SOCIAL QUESTIONS|health|medical science

    #646211

    IATE #3528758
    staidéar deirmeach in vivo Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    In-vivo-Test auf Hautreizung/-verätzung | In-vivo-Hauttest
    de
    Definition Untersuchung an der Haut am lebenden Organismus Reference "Deutscher Fachmann für Medizin 2017 nach NetDoktor, s. v. „Pricktest“, http://www.netdoktor.de/diagnostik/allergietest/pricktest/ (21.7.2017)"
    in vivo dermal study | dermal in vivo study
    en
    étude cutanée in vivo
    fr