SCIENCE|natural and applied sciences|life sciences
- scrios Reference COM-GA
- ga
- Verlust von Chromosomenabschnitten | Verlust von Genabschnitten | Deletion
- de
- Definition Chromosomen-Mutation, bei der mindestens ein Basenpaar, häufig jedoch mehrere oder sogar sehr viele Basenpaare aus der DNA des betreffenden Organismus entfernt wurden Reference Lexikon der Biologie. Spektrum Akademischer Verlag: Heidelberg, 1999, s. v. „Deletion“, http://www.spektrum.de/lexikon/biologie/deletion/17174 (10.10.2017)
- Comment Bei der Deletion kann ein interkalar (in der Mitte) oder terminal (endständig) lokalisiertes Chromosomen- oder Chromatidenstück verlorengehen. Den Verlust endständiger Chromosomenstücke bezeichnet man auch als Defizienz.
- deleted gene | deletion | deleted genes | deletions
- en
- Definition absence of a segment of DNA Reference NCBI » Bookshelf » GeneReviews » Illustrated Glossary http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=glossary&rendertype=def-item&id=deletion [20.10.2010]
- Comment It may be as small as a single base or large enough to encompass one or more entire genes. (See also: gene deletion [ IATE:3571263 ]If the deletions occur outside of coding regions, they may have negligible effects on phenotype, unless they affect the expression of nearby genes.Within a coding region, the deletion of exactly three, six, nine or an exact multiple of three nucleotids results in the elimination of one, two, three or a number of amino acids from the encoded polypeptide chain, because three nucleotides is the length of a codon.If the length of the deletion is not an exact multiple of three nucleotides, the mutation shifts the phase in which the ribosome reads the triplet codons and consquently alters all of the amino acids downstream for the site of the mutation (frameshift mutation IATE:1687482 ) Ref: Daniel L. Hartl, Elizabeth W. Jones. Genetics: analysis of genes and genomes http://books.google.com/books?id=cfvILxY9tCIC&pg=PA515&lpg=PA515&dq=If+the+deletion+occurs+within+a+coding+region&source=bl&ots=GT9hPjHWEA&sig=mo0jDaGZ1P3fT34ZMNlU9oTPCkg&hl=en&ei=Hau-TOvoN4uUOr_osDw&sa=X&oi=book_result&ct=result&resnum=6&ved=0CCcQ6AEwBQ#v=onepage&q=If%20the%20deletion%20occurs%20within%20a%20coding%20region&f=false [20.10.2010]See also: - deletion mutation [ IATE:3571974 ]
- délétion
- fr
- Definition aberration chromosomique consistant en la perte d’un segment de chromosome Reference Dictionnaire illustré des termes de médecine 31ème édition > délétion, M. Garnier & V. Delamare, 2012, Maloine, Paris, ISBN 978-2-224-03257-9 [9.1.2018]
- Comment La délétion affecte soit un chromosome («délétion chromosomique»), soit un gène dudit chromosome («délétion de gène» [IATE:3571263 ]). Elle produit une information génétique tronquée et peut entraîner des malformations. (Source: «Délétion, génétique», D. Lavergne, Encyclopædia Universalis en ligne, http://www.universalis.fr/encyclopedie/deletion-genetique/ [9.1.2018]) Voir aussi: - aberration chromosomique [IATE:1667034 ] - mutation par délétion [IATE:3571974 ] - mutation [IATE:1254707 ]