SOCIAL QUESTIONS|health|medical science
- gaschill mhéiseincíoma Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- mesenchymal stem cell | MSC
- en
- Definition "any pluripotent cell found in bone marrow that can differentiate into a variety of cell types found in the skeletal tissues, such as bone cells (osteoblasts), cartilage cells (chondrocytes), and fat cells (adipocytes)" Reference "COM-EN, based on:EuroStemCell. 'Mesenchymal stem cells: the 'other' bone marrow stem cells' (20.5.2020)"
- Comment "1) These are not to be confused with haematopoietic (blood) stem cells that are also found in bone marrow and make our blood.2) The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee issued a position paper in 2005 clarifying that the term mesenchymal stem cell is not equivalent or interchangeable with mesenchymal stromal cell (MSC). The former refers to a stem cell population with demonstrable progenitor cell functionality of self-renewal and differentiation, whereas the latter refers to a bulk population with notable secretory, immunomodulatory and homing properties. The ISCT's MSC committee further issued a minimal criteria to define multipotent MSCs as being plastic adherent, expressing CD73, CD90 and CD105, lacking the expression of hematopoietic and endothelial markers CD11b, CD14, CD19, CD34, CD45, CD79a and HLA-DR and capable of in vitro differentiation into adipocyte, chondrocyte and osteoblast lineages"