SOCIAL QUESTIONS|health|pharmaceutical industry
- cinéitic neamhlíneach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- non-linear pharmacokinetics | Nonlinear pharmacokinetics | non-linear pharmacokinetic profile | non-linear kinetics
- en
- Definition relationship between the various factors involved in the fate of a substance administered externally to a living organism which is represented by a non-linear curve because of time or dose dependences in pharmacokinetic parameters Reference "COM-Terminology Coordination, based on:Ludden TM. Nonlinear pharmacokinetics: clinical Implications. Clin Pharmacokinet. 1991 Jun;20(6):429-46, http://www.ncbi.nlm.nih.gov/pubmed/2044328 [30.10.2014]"
- Comment Nonlinear kinetics is usually due to saturation occuring in one of the pharmacokinetic mechanisms: protein binding, hepatic metabolism, or active renal transport of the drug.