Gaois

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  1. SOCIAL QUESTIONS|health|pharmaceutical industry

    #619184

    IATE #1105852
    cinéitic neamhlíneach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    nicht-lineare Kinetik
    de
    non-linear pharmacokinetics | Nonlinear pharmacokinetics | non-linear pharmacokinetic profile | non-linear kinetics
    en
    Definition relationship between the various factors involved in the fate of a substance administered externally to a living organism which is represented by a non-linear curve because of time or dose dependences in pharmacokinetic parameters Reference "COM-Terminology Coordination, based on:Ludden TM. Nonlinear pharmacokinetics: clinical Implications. Clin Pharmacokinet. 1991 Jun;20(6):429-46, http://www.ncbi.nlm.nih.gov/pubmed/2044328 [30.10.2014]"
    Comment Nonlinear kinetics is usually due to saturation occuring in one of the pharmacokinetic mechanisms: protein binding, hepatic metabolism, or active renal transport of the drug.
    cinétique non linéaire
    fr