SCIENCE|natural and applied sciences|life sciences|pharmacology
- freasaitheach gabhdóra Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- antagonist | receptor antagonist
- en
- Definition "drug that reduces the action of another drug, generally an agonist " Reference "RICHARD R. NEUBIG, MICHAEL SPEDDING, TERRY KENAKIN, AND ARTHUR CHRISTOPOULOS. 'International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology' (4.2.2022). PHARMACOLOGICAL REVIEWS. Vol. 55, No. 4. The American Society for Pharmacology and Experimental Therapeutics"
- Comment Can be competitive or non-competitive, each of which can be reversible or irreversible. A competitive antagonist binds to the same site as the agonist but does not activate it, thus blocks the agonist’s action. A non-competitive antagonist binds to an allosteric (non-agonist) site on the receptor to prevent activation of the receptor. A reversible antagonist binds non-covalently to the receptor, therefore can be “washed out”. An irreversible antagonist binds covalently to the receptor and cannot be displaced by either competing ligands or washing.