SCIENCE|natural and applied sciences|life sciences|biology
- caidéal eisilte ildrugaí Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ie Faomhadh an téarma seo mar chuid de Thionscadal Lex"
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- multidrug efflux pump
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- Definition transport protein, found in both Gram-positive and -negative bacteria as well as in eukaryotic organisms, and involved in the extrusion of antimicrobials from within cells into the external environment Reference "COM-Terminology Coordination, based on: - M.A. Webber, L.J.V. Piddock. 'The importance of efflux pumps in bacterial antibiotic resistance' (18.3.2022). 2003. Journal of Antimicrobial Chemotherapy, 51(1)- Blanco P, Hernando-Amado S, Reales-Calderon JA, et al. 'Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants' (18.3.2022). Microorganisms. 2016;4(1):14. Published 2016 Feb 16."
- Comment Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug resistance (MDR).