Gaois

This is a static copy of data that is exported from IATE on an occasional basis. It should not be assumed that information provided about an entry here will always correspond to the current version of the entry in IATE. That current version can be checked by clicking on the link on the upper right hand side of each entry. More information »

1 result

  1. SCIENCE|natural and applied sciences|life sciences|biology

    #664880

    IATE #3593035
    deisiú briste aonribe Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ie Faomhadh an téarma seo mar chuid de Thionscadal Lex"
    ga
    SSB repair | single strand break repair | SSBR
    en
    Definition "mechanism that repairs normal and abnormal single strand breaks that arise either from reactions with DNA-damaging agents (endogenous or exogenous) or as intermediates in certain enzymatic events" Reference "COM-Terminology Coordination, based on: Abbotts, R., Wilson, D. M. 3rd., 'Coordination of DNA single strand break repair' (2.3.2021), Free Radical Biology and Medicine 2017; 107:228-244, doi:10.1016/j.freeradbiomed.2016.11.039"
    Comment In brief, SSBR consists of 1) strand break detection; 2) removal of 5′- or 3′-terminal blocking group; 3) gap-filling repair synthesis; and 4) nick-sealing by a DNA ligase. As reviewed herein, two proteins key to orchestrating SSBR are poly(ADP-ribose) polymerase 1 (PARP1) and X-ray cross-complementing protein 1 (XRCC1).