Gaois

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  1. SCIENCE|natural and applied sciences|life sciences|biology

    #685131

    IATE #3580503
    damage-associated molecular pattern | DAMP | danger-associated molecular pattern | DAMPs | alarmin
    en
    Definition molecule passively released from dying cells of an organism due to damage, trauma, ischemia, or infection-induced necrosis and which is host cell derived and both initiates and perpetuates innate immune responses Reference "COM-Terminology Coordination, based on: Hyong Woo Choi and Daniel F. Klessig. DAMPs, MAMPs, and NAMPs in plant innate immunity. BMC Plant Biol. 2016; 16: 232. (29.3.2019)"
    Comment It is generally accepted that these defenses help protect the damaged tissue, which is vulnerable to infection due to the disruption of physical barriers that would otherwise prevent microbial ingress. In mammals, inflammation is another component of the innate immune response; it not only helps to prevent/suppress infection, but also aids in healing.