Gaois

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12 results

  1. SOCIAL QUESTIONS|health|medical science · SCIENCE|natural and applied sciences|life sciences

    #617694

    IATE #1073785
    eipeatóp Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Antigendeterminant | antigene Determinante | determinante Gruppe | Epitop | determinierende Gruppe | Determinante | antigenes Motiv | Rezeptor
    de
    Definition umschriebener Bezirk eines Antigenmolekuels, der dessen Spezifitaet bestimmt Reference Reallex Med
    epitope | antigenic determinant | antigenic site
    en
    Definition "part of an antigen which is recognised by the immune system" Reference "Wikipedia > Epitope (19.8.2020)"
    Comment More specifically it is the part of the antigen that is recognised by antibodies, B cells, or T cells.For example, the epitope is the specific piece of the antigen to which an antibody binds. Sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes.
    épitope | déterminant antigénique | site antigénique
    fr
    Definition Conformation moléculaire d'une séquence d'acides aminés(contigus ou non)du site antigénique(voir ce mot)qui est reconnue par un anticorps monoclonal et qui se lie à lui.Un seul site antigénique peut exprimer plusieurs épitopes.; lors de la réponse immunitaire spécifique, l'anticorps identifie une (ou plusieurs) stucture située à la surface de la molécule d'antigène, le déterminant antigénique, dit encore site antigénique, qui répond à une structure similaire au niveau de l'anticorps, le site anticorps; jusqu'à un certain point, ce sont les déterminants antigéniques qui décident de la nature, humorale ou cellulaire, de la réponse immunitaire dirigée contre l'antigène ou, au contraire, de la tolérance immunitaire Reference Biofutur 27/84,p.23; GLTM
  2. SCIENCE|natural and applied sciences|life sciences|biology

    #634423

    IATE #1684624
    gabhdóir Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Rezeptor
    de
    receptor
    en
    Definition macromolecule in the membrane or inside the cell that specifically (chemically) binds a ligand (drug) Reference "COM-EN, based on:The Journal of the International Federation of Clinical Chemistry and Laboratory Medicines (EJIFCC), 2008 Apr; 19(1): 48-53 > Pharmacogenetics of Drug Receptors (28.4.2020)"
    Comment "Receptor theory is the backbone of pharmacology. The principles of receptor function have provided mechanistic explanations of great utility in pharmacology and therapeutics for understanding drug properties such as specificity, potency, and efficacy.Reference: Allan B. Okey. An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI. (28.4.2020) Toxicol. Sci. (2007) 98 (1): 5-38."
    récepteur
    fr
    Definition au niveau cellulaire, ce sont des molécules protéiques situées sur la membrane ou dans la cellule et agissent au niveau du noyau, capables d'accueillir des molécules endogènes ou des médicaments spécifiques Reference FRM,Gloss.textes scientifiques,mars 1998
  3. SOCIAL QUESTIONS|health|pharmaceutical industry

    #617605

    IATE #1073476
    gabhdóir aidréineirgeach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    adrenerger Rezeptor
    de
    adrenergic receptor | adrenoreceptor
    en
    Definition "class of receptors that are targets of the catecholamines [ IATE:1506050 ], especially norepinephrine (noradrenaline) and epinephrine (adrenaline)" Reference "COM-EN, based on:Adrenergic receptor. http://en.wikipedia.org/wiki/Adrenergic_receptor [11.5.2012]"
    Comment "Although dopamine is a catecholamine, its receptors are in a different category.There are two main groups of adrenergic receptors, α and β, with several subtypes. For more information, see: Adrenergic receptor. http://en.wikipedia.org/wiki/Adrenergic_receptor [12.6.2012] & David Goodsell & RCSB Protein Data Bank. Adrenergic Receptors http://www.rcsb.org/pdb/101/motm.do?momID=100 [12.6.2012]"
    récepteur adrénergique | adrénorécepteur
    fr
  4. SOCIAL QUESTIONS|health|pharmaceutical industry

    #639229

    IATE #2224770
    blocálaí gabhdóirí angaitheannaine Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Angiotensin-Rezeptor-Blocker | ARB | Angiotensin II-Hemmer | Angiotensin II-Antagonist
    de
    Definition Medikament zur Hemmung der Wirkung des Hormons Angiotensin II Reference "eesom, http://www.eesom.com/de/anginapectoris.php (01.06.2007)"
    Comment wirkt als spezifischer Hemmstoff am Subtyp 1 des Angiotensin-II-Rezeptors und senkt den Gefäßwiderstand im Körper
    angiotensin-receptor blocker | angiotensin II inhibitor | AII inhibitor | ARB | angiotensin receptor antagonist | ARA | angiotensin II type 1 receptor blocker | angiotensin II type 1 receptor antagonist
    en
    Definition hypertension drugs that prevent angiotensin II from binding with its receptors on the surface of the cells Reference COM/DGT-Terminology Coordination
    Comment "the hypertension drugs that prevent the conversion of angiotensin I to angiotensin II are called ""angiotensin-converting enzyme inhibitors"" (ACE inhibitors or ACEI) [ IATE:1040702 ]. For more information, see also: Angiotensin II Receptor Blockers http://www.ti.ubc.ca/pages/letter28.htm [31.5.2007]"
    antagoniste des récepteurs de l'angiotensine II | ARA II | ARA-II | ARAII | ARA | bloqueur des récepteurs de l'angiotensine II | antagoniste des récepteurs AT1 de l'angiotensine II | bloqueur des récepteurs AT1 de l'angiotensine II
    fr
    Definition médicament pour le traitement de l'hypertension et de l'insuffisance cardiaque congestive qui bloque la fixation de l'angiotensine sur ses récepteurs (AT1 , AT2) Reference "Sur la base de: Facultés universitaires Notre-Dame de la Paix, Namur, http://www.fundp.ac.be/recherche/projets/page_view/94273108/ [1.6.2007] et amc.ca, Racine N., White M. Le rôle des bloqueurs des récepteursde AT-II dans l'insuffisance cardiaque congestive, http://www.cma.ca/index.cfm/ci_id/24826/la_id/2.htm [1.6.2007]"
    Comment "il existe deux sortes de récepteurs de l'angiotensine, les récepteurs AT1 et les récepteurs AT2. La plupart des médicaments bloquent les récepteurs AT1. A ne pas confondre avec les médicaments qui inhibent la production de l'angiotensine II [ IATE:1040702 ]"
  5. SOCIAL QUESTIONS|health|medical science

    #617606

    IATE #1073479
    gabhdóir aicéitiolchoilín Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    cholinergischer Neurotransmitter-spezifischer Rezeptor | cholinergischer Rezeptor
    de
    Definition Rezeptor der acetylcholin-ausschüttend wirkt. Reference Buddecke p.508
    cholinergic receptor | acetylcholine receptor | AChR | cholinoceptor
    en
    Definition any of the sites in effector cells or at synapses through which acetylcholine exerts its action Reference "'cholinergic receptor' (29.4.2020), The Free Dictionary."
    Comment "They are of two types: muscarinic and nicotinic cholinergic receptors."
    récepteur cholinergique | récepteur de l'acétylcholine
    fr
  6. SOCIAL QUESTIONS|health|pharmaceutical industry

    #602767

    IATE #202511
    gabhdóir dopaimín Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Dopamin-Rezeptor
    de
    dopamine receptor
    en
    Definition "receptor [ IATE:1684624 ] whose primary endogenous ligand [ IATE:1463918 ] is the neurotransmitter [ IATE:1073475 ] dopamine [ IATE:1894513 ]" Reference "COM-EN, based on: Philip G. Strange. DOPAMINE RECEPTORS. Tocris Cookson Ltd http://web.unife.it/sezione/fisiologia/DA%20Pharmacology/Literature/dopreview.pdf [25.5.2012]"
    récepteur de la dopamine
    fr
  7. SOCIAL QUESTIONS|health|pharmaceutical industry

    #602766

    IATE #202505
    gabhdóir mu-ópóideach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    MU-Rezeptor
    de
    mu receptor | μ-receptor | mu-opioid receptor | μ-opioid receptor | MOP
    en
    Definition "class of opioid receptors [ IATE:1666898 ] mediating analgesia (pain relief), hypothermia, respiratory depression , miosis (constricted pupils), bradycardia [ IATE:1499659 ], nausea, euphoria and physical dependence" Reference "COM-EN, based on:EMBL-EBI. IPR000105 Mu opioid receptor http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000105 [16.5.2012]"
    Comment "Beta-endorphin is the most potent endogenous ligand [ IATE:1463918 ].The receptors were named using the first letter of the first ligand that was found to bind to them. Morphine was the first chemical shown to bind to mu receptors. The first letter of the drug morphine is m, but in biochemistry there is a tendency to use Greek letters, thus turning the m to μ."
    récepteur 'mu'
    fr
  8. SCIENCE|natural and applied sciences|life sciences|biology

    #635595

    IATE #1757859
    gabhdóir NMDA Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    NMDA-Rezeptor
    de
    Definition der biophysikalische Prozeß, der zur Ausbildung von LTP führt, ist formal der Hebb-Regel sehr ähnlich. Eine wichtige Rolle bei der Veränderung der Synapsenstärke spielt der NMDA (N-methyl-D-aspartat)-Rezeptor. Dieser Rezeptor erlaubt einen Einstrom von Calcium in die Synapse nur dann, wenn sowohl die präsynaptische als auch die postsynaptische Nervenzelle gleichzeitig aktiv sind. Dieser Einstrom setzt dann einen Prozeß in Gang, der zur Verstärkung der Synapse führt Reference McNaughton,1987
    NMDA receptor | NMDAR | NMDARs
    en
    Definition glutamate-gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms Reference "Blanke ML, VanDongen AMJ. 'Activation Mechanisms of the NMDA Receptor' (15.4.2021). In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 13."
    Comment They are critical for the development of the central nervous system (CNS), generation of rhythms for breathing and locomotion, and the processes underlying learning, memory, and neuroplasticity. Consequently, abnormal expression levels and altered NMDAR function have been implicated in numerous neurological disorders and pathological conditions.
    récepteur NMDA | récepteur du N-méthyl D-aspartate
    fr
    Definition processus biophysique qui gère la potentialisation à long terme; le récepteur fixe un acide aminé synthétique, le N-méthyl D-aspartate; lorsque les cellules présynaptiques et postsynaptiques sont simultanément actives, des ions calcium entrent dans les cellules Reference Pour la Science,11.92,77
  9. SCIENCE|natural and applied sciences|life sciences · SCIENCE|natural and applied sciences|life sciences|biology · SCIENCE|natural and applied sciences|life sciences|pharmacology

    #602768

    IATE #202522
    gabhdóir tras-scannáin Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir scannáin Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    gabhdóir dromchla cille Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Rezeptor an der Zelloberfläche
    de
    cell-surface receptor | transmembrane receptor | membrane receptor
    en
    Definition protein attached to the cell membrane thats bind signalling molecules external to the cell with high affinity and converts this extracellular event into one or more intracellular signals that alter the behavior of the target cell Reference "COM-Terminology Coordination, based on: From Alberts, Molecular Biology of the Cell, 2nd ed, pp 693-5 cited in: University of Massachusets Medical School. 'Receptors, Cell Surface' (18.2.2020). MeSH Information"
    récepteur à la surface d'une cellule
    fr
  10. SOCIAL QUESTIONS|health|pharmaceutical industry

    #620774

    IATE #1150092
    gabhdóir ópóideach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Rezeptor für Opiate | Opiat-Rezeptor
    de
    opioid receptor | receptors
    en
    Definition "receptor with opioids [ IATE:3529317 ] as ligands" Reference "Wikipedia. Opioid receptor http://en.wikipedia.org/wiki/Opioid_receptor [16.5.2012]"
    Comment There are three principal classes of opioid receptors, μ, κ, δ (mu, kappa, and delta), although up to seventeen have been reported, and include the ε, ι, λ, and ζ (Epsilon, Iota, Lambda and Zeta) receptors.
    récepteur opioïde
    fr
    Definition récepteur cérébral des opiacés Reference Pour la Science,mai 1991
  11. SOCIAL QUESTIONS|health|medical science · SOCIAL QUESTIONS|health|pharmaceutical industry

    #648067

    IATE #3540742
    measúnacht nascachta idir gabhdóir agus liogann Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Rezeptor-Assay
    de
    receptor-assay | receptor assay | receptor binding assay | receptor-ligand binding assay
    en
    Definition "assay1 that determines the binding affinity between a ligand and its receptor2 molecule or ligand efficacy (the biological effect and the magnitude of the effect when the ligand binds to its receptor)1 assay [ IATE:1472211 ] 2 receptor [ IATE:1684624 ]" Reference "COM-Terminology Coordination, based on:Accelero Bioanalytics. Welcome to the World of Ligand Binding Assays, http://www.accelero-bioanalytics.com/en/science/ligand-binding-assays [6.3.2014]"
    Comment "A ligand is a substance that binds with a target biomolecule (receptor).Further reading:- Okey A.B. An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI Toxicol. Sci. (2007) 98 (1): 5-38, http://toxsci.oxfordjournals.org/content/98/1/5.full and especially the part referring to the receptor theory, http://toxsci.oxfordjournals.org/content/98/1/5.full#sec-28 [6.3.2014]- Accelero Bioanalytics. Welcome to the World of Ligand Binding Assays, http://www.accelero-bioanalytics.com/en/science/ligand-binding-assays [6.3.2014] See also: - cell-based assay (related) [ IATE:3540739 ]"
    test d'interaction récepteur
    fr
  12. SCIENCE|natural and applied sciences|life sciences|biology

    #602761

    IATE #202119
    inchíotóis trí mheán gabhdóirí Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    rezeptor-gekoppelte Endocytose
    de
    receptor-mediated endocytosis | RME
    en
    Definition "form of endocytosis by which cells absorb specific target molecules (metabolites, hormones, proteins – and in some cases viruses), which are captured by receptor proteins on the cell surface" Reference "COM-Terminology Coordination, based on: - Wikipedia > Receptor-mediated endocytosis (17.3.2021)- Khan Academy. 'Bulk transport' (17.3.2021)"
    endocytose par récepteurs
    fr