SOCIAL QUESTIONS|health|medical science
- apaptóis Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- apoptosis | programmed cell death | PCD
- en
- Sainmhíniú process of programmed cell death Tagairt "'Apoptosis' (23.1.2025). US National Human Genome Research Institute"
- Nóta "1) It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a role in preventing cancer. If apoptosis is for some reason prevented, it can lead to uncontrolled cell division and the subsequent development of a tumor.2) Resistance towards apoptosis also contributes to drug resistance and is associated with poor clinical prognosis. Cancer cells can escape apoptosis by either inactivating pro-apoptotic genes, or by counteracting their function.3) There are two apoptotic pathways, the extrinsic one, that is initiated by the interaction of cell surface exposed death receptors, belonging to the superfamily of tumor necrosis factor receptor (TNFR), with their respective protein TNF family ligands, and the intrinsic mitochondria-dependent pathway, that is mediated by intracellular signals that converge at the mitochondrial level in response to different stress conditions (i..e, irradiation, treatment with chemotherapeutic agents, etc.)."
- apoptosis
- la