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3 thoradh

  1. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664352

    IATE #3591832
    núicléáis méire since Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    zinc finger nuclease | ZFN
    en
    Sainmhíniú any of a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations Tagairt "COM-Terminology Coordination, based on: Merck. What Is ZFN Technology? (16.11.2020)"
    Nóta Each Zinc Finger Nuclease (ZFN) consists of two functional domains: a.) A DNA-binding domain comprised of a chain of two-finger modules, each recognizing a unique hexamer (6 bp) sequence of DNA. Two-finger modules are stitched together to form a Zinc Finger Protein, each with specificity of ≥ 24 bp. b.) A DNA-cleaving domain comprised of the nuclease domain of Fok I. When the DNA-binding and DNA-cleaving domains are fused together, a highly-specific pair of 'genomic scissors' are created.
  2. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664364

    IATE #3591851
    spriocmhodhnú géanóim trí mheán ZFN Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    ZFN-mediated targeted genome editing
    en
    Sainmhíniú "genome editing that takes place in the nucleus when a zinc finger nuclease (ZFN) pair targeting the user’s gene of interest is delivered into a parental cell line, either by transfection, electroporation or viral delivery." Tagairt "Merck. What Is ZFN Technology? (16.11.2020)"
  3. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664661

    IATE #3592538
    teicníc núicléáise méire since Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    teicníc ZFN Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    zinc finger nuclease technique | ZFN technique | ZFN-1 | ZFN-2 | ZFN-3
    en
    Sainmhíniú "gene modification technique using zinc finger nuclease" Tagairt "COM-Terminology Coordination, based on: EFSA Panel on Genetically modified organisms (GMO); 'Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function' (26.1.2021). EFSA Journal 2012;10(10):2943. [31 pp.] doi:10.2903/j.efsa.2012.2943. Available online: www.efsa.europa.eu/efsajournal"
    Nóta "So far there are three different techniques. For more information, see: EFSA Panel on Genetically modified organisms (GMO); 'Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function' (26.1.2021). EFSA Journal 2012;10(10):2943. [31 pp.] doi:10.2903/j.efsa.2012.2943. Available online: www.efsa.europa.eu/efsajournal"