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  1. SOCIAL QUESTIONS|health|pharmaceutical industry

    #648722

    IATE #3543791
    blocálaí néaramhatánach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    neuromuscular blocking drug | neuromuscular blocking agent | neuromuscular junction blocking agent
    en
    Sainmhíniú "any drug which blocks neuromuscular transmission at the neuromuscular junction [ IATE:1232550 ] causing paralysis of the affected skeletal muscles" Tagairt "Wikipedia. Neuromuscular-blocking drug http://en.wikipedia.org/wiki/Neuromuscular-blocking_drug [16.5.2012]"
    Nóta This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate. While there are drugs that act presynaptically (such as botulinum toxin and tetanus toxin), the clinically-relevant drugs work postsynaptically.In clinical use, neuromuscular block is used adjunctively to anesthesia to produce paralysisThese drugs fall into two groups: 1) Depolarising blocking agents 2) Non-depolarising blocking agents