SCIENCE|natural and applied sciences|life sciences|biology|microorganism · SCIENCE|natural and applied sciences|life sciences
- víreas póilió vacsaíndíorthaithe Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- vaccine derived poliovirus | VDPV
- en
- Sainmhíniú "vaccine-related poliovirus which has a high level of VP1 sequence divergence from their parental OPV strains (>1% [types 1 and 3] or >0.6% [type 2]) indicating prolonged replication (or transmission) of the vaccine virus" Tagairt COM-Terminology Coordination, based on:
- Nóta -'Wild polioviruses are distinct and are not genetically linked to vaccine polioviruses.VDPVs are classified into three categories: a) circulating VDPVs (cVDPV) b) immune-deficiency-related VDPV (iVDPV), c) ambiguous VDPV (aVDPV). VDPVs reported as ambiguous VDPVs might later qualify to be iVDPV or cVDPV. The aVDPVs commonly occur in countries of low rates of polio vaccination coverage and could signal cVDPV emergence and gaps in immunization and surveillance activities' 1 -'The terminology can be confusing, because in principle all clinical and environmental vaccine-related poliovirus isolates can be considered to be vaccine derived. However, the term “VDPV” is specifically reserved for isolates whose extent of sequence divergence from the parental OPV strains indicates prolonged replication or transmission. The definitions follow from the poliovirus molecular clock, which ticks at an overall rate in which approximately 1% of nucleotides undergo substitution per year. Thus, vaccine-related viruses that differ from the corresponding OPV strain by >1% of nucleotide positions are estimated to have replicated in 1 or more persons for at least 1 year after administration of an OPV dose. The demarcation for type 2 VDPVs (VDPV2s) was lowered to 0.6% to increase the sensitivity for early detection of cVDPV2 outbreaks. 2'
- poliovirus dérivé d'une souche vaccinale | PVDV
- fr
- Sainmhíniú virus de la polio provenant d'une forme affaiblie du virus utilisée dans les vaccins, qui continue à circuler après excrétion, peut subir des mutations et se transmettre au sein de populations ayant une très faible immunité, dans des zones où l'assainissement est insuffisant Tagairt "COM-FR, d'après:Site de l'OMS, «Qu'entend-on par poliovirus dérivé d'une souche vaccinale? - Questions réponses» (18.12.2019)"