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16 toradh

  1. SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer

    #690570

    IATE #3648381
    tnáitheadh T-cheall Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-cell exhaustion
    en
    Sainmhíniú state of T-cell dysfunction arising from persistent activation in response to chronic antigen exposure, such as during chronic viral infections or cancer Tagairt "Ishita Gupta, Ola Hussein, Konduru Seetharama Sastry, Salim Bougarn, Neha Gopinath, Evonne Chin-Smith, Yashi Sinha, Hesham Mohamed Korashy, Cristina Maccalli. 'Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications' (21.11.2024). Advances in Cancer Biology - Metastasis Volume 8, October 2023, 100107"
  2. SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer

    #690561

    IATE #3648368
    imdhíon-teiripe T-cheall uchtaíoch Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    adoptive T cell immunotherapy
    en
    Sainmhíniú "type of immunotherapy in which T cells are given to a patient to help the body fight diseases, such as cancer" Tagairt "COM-Terminology Coordination, based on: 'adoptive cell therapy' (20.11.2024). NCI Dictionary of Cancer Terms. National Cancer Institute. US National Institutes of Health "
  3. SOCIAL QUESTIONS|health|medical science

    #628272

    IATE #1431863
    cill T4 limficíte Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T4-Helferzelle | CD4-T-Zelle | TH | T-Helferzelle | T-Helfer-Lymphoidozellen | Helferzellen
    de
    T4 cell | CD4 T-lymphocyte | CD4 T cell | CD4+ | CD4 lymphocyte | CD4+ T4 lymphocyte | T4 helper | CD4+ T4 helper | helper lymphocyte | helper cell | T-helper cell | helper T-cell | helper T lymphocyte | helper CD4 cell | inducer T-lymphocyte | helper-inducer T-cell | inducer cell
    en
    Sainmhíniú "T cell 1 bearing on its surface the glycoprotein CD4 (cluster of differentiation 4), and functions by inducing the nearby cell to differentiate, as in triggering precursor T cells to differentiate into mature T cells 1 T cell [ IATE:1431862 ]" Tagairt "COM-Terminology Coordination, based on: ""Helper-inducer T cell"". Biology Online, http://www.biology-online.org/dictionary/Helper-inducer_T_cell [14.10.2014]"
    Nóta The T in T cell stands for thymus. The thymus is the bodily organ where T cells mature. This type of T cell is severely decreased in number in patients suffering from AIDS.
    lymphocyte T auxiliaire | lymphocyte auxiliaire | T facilitant | lymphocyte CD4 | helpers | lymphocyte T4 | lymphocytes T amplificateurs | cellule CD4 | cellule T4 | lymphocyte T helper | CD4 | lymphocyte T inducteur
    fr
    Sainmhíniú lymphocyte appartenant à une sous-population de lymphocytes issus du thymus, principale cible du virus du VIH, qui porte à sa surface une protéine appelée CD4(anciennement T4) ; Variété de lymphocytes dont l'action est complémentaire à celle des lymphocytes B pour la production d'anticorps et à celle d'autres lymphocytes T dans l'immunité à médiation cellulaire. ; lymphocyte qui déclenche la maturation des lymphocytes T:il provoque la transformation des précurseurs en cellules fonctionnellement distinctes Tagairt SEC:Rozembaum,W.,Immunologie,Les dossiers du praticien n° 62,Sida:guide pratique 1990,p.31 ; ; N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991
    Nóta Les lymphocytes T auxiliaires sécrètent deux facteurs: l' interleukine 2 et l' interféron gamma. Le VIH a un tropisme pour les lymphocytes T auxiliaires car ils possèdent la molécule CD4. L'une des manifestations biologiques du SIDA est donc la disparition des lymphocytes auxiliaires chez le malade. ;
  4. SOCIAL QUESTIONS|health|medical science

    #631920

    IATE #1586515
    limficít chíteatocsaineach Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    zytotoxische Zelle | Zytotoxischer T-Lymphozyt | zytotoxische T-Zelle
    de
    Sainmhíniú Immunkompetente Zelle, die ohne Komplement über direkten Kontakt zur Zytolyse bestimmter Zielzellen führen. Tagairt RL p.1872
    T8 lymphocyte | T8 cell | CD8 cell | CD8 T lymphocyte | CD8 lymphocyte | CD8+ T cell | CD8+ cell | cytotoxic T cell | cytotoxic T lymphocyte
    en
    Sainmhíniú "type of T cell1 that expresses CD8 (cluster of differentiation 8) transmembrane glycoprotein, and functions by inhibiting, suppressing, or helping to stop an immune response by releasing signals to other immune cells1 T cell [ IATE:1431862 ]" Tagairt "COM-Terminology Coordination, based on:""Suppressor T cell"". Biology Online, http://www.biology-online.org/dictionary/Suppressor_T_cell [14.10.2014]"
    lymphocyte T8 | lymphocyte cytotoxique | CTL | cellule CD8 | lymphocyte T cytotoxique | cellule T lytique | cellule OKT8 | cellule T8 | lymphocyte CD8 | lymphocyte OKT8
    fr
    Sainmhíniú lymphocyte T8:lymphocyte T présentant la molécule CD8 à sa surface. Cette classe de globules blancs comprend les lymphocytes T cytotoxiques et les lymphocytes T suppresseurs, et joue un rôle prépondérant dans la régulation du système immunitaire ; seule espèce de lymphocytes T capable de défendre l'organisme de façon active Tagairt N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991 ; N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991
  5. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology · SOCIAL QUESTIONS|health|pharmaceutical industry · SOCIAL QUESTIONS|health|illness|cancer

    #684942

    IATE #3578242
    T-chill gabhdóra chiméaraigh aintaiginí Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    chimeric antigen receptor T cell | CAR T cell | CAR-T cell
    en
    Sainmhíniú "T-lymphocyte which is genetically modified by adding a gene expressing a special receptor (called a chimeric antigen receptor) through which it is targeted against surface components of tumour cells in order to kill those cells" Tagairt "COM-Terminology Coordination, based on:Kieran Breen. 'Chimeric antigen receptor (CAR) T cell therapies' (30.4.2024). European Medicines Agency (EMA)"
  6. SOCIAL QUESTIONS|health|medical science

    #684941

    IATE #3578241
    teiripe T-cheall le gabhdóir ciméarach aintaiginí Tagairt "Faofa ag an gCoiste Téarmaíochta, www.tearma.ie ;Faomhadh an téarma seo mar chuid de Thionscadal Lex"
    ga
    chimeric antigen receptor T cell therapy | CAR T cell therapy | CAR-T cell therapy | CAR-Tcell therapy
    en
    Sainmhíniú "type of treatment with CAR T-cells derived from a patient’s own blood (autologous) or derived from a healthy person (allogenic) which are grown in large numbers in the laboratory and then given to the patient by infusion" Tagairt "COM-Terminology Coordination, based on:Kieran Breen, Chimeric antigen receptor (CAR) T cell therapies (1.2.2021), European Medicines Agency (EMA)"
    Nóta Memorial Sloan Kettering Cancer Center (MSK) announced on 14.9.2023 that Michel Sadelain, MD, PhD, renowned physician-scientist, Director of the Center for Cell Engineering, and Stephen and Barbara Friedman Chair, has been awarded the 2024 Breakthrough Prize in Life Sciences. The prestigious prize recognizes Dr. Sadelain and Carl June, MD, of the University of Pennsylvania, for the development of chimeric antigen receptor T cell immunotherapy (CAR T cell therapy) whereby the patient’s T cells are modified to target and kill cancer cells. Dr. Sadelain is a pioneer and leader in the field of immunology, genetic engineering, and the development of CAR T cell therapy. A type of immunotherapy, CAR T cell therapy uses genetically engineered versions of a person’s own immune cells to find and fight cancer.
  7. SOCIAL QUESTIONS|health|medical science|immunology

    #677108

    IATE #1073436
    T-chill éifeachtóra Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-Inducer-Zellen
    de
    effector T cell
    en
    Sainmhíniú "T cell with limited life span involved in adaptive immunity that has differentiated further after exposure to an antigen and provides the immune system with ""memory"" against previously encountered pathogens" Tagairt "COM-Terminology Coordination, based on:- ASTRO. 'T Cell Activation and Effector Functions' (3.5.2024)- PluriSelect. 'Effector T cells' (3.5.2024)- Wikipedia > T cell (3.5.2024)"
    Nóta "Antigen-naive T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen within the context of an MHC molecule on the surface of a professional antigen presenting cell (e.g. a dendritic cell). Appropriate co-stimulation must be present at the time of antigen encounter for this process to occur. Historically, memory T cells were thought to belong to either the effector or central memory subtypes, each with their own distinguishing set of cell surface markers (see below).[19] Subsequently, numerous new populations of memory T cells were discovered including tissue-resident memory T (Trm) cells, stem memory TSCM cells, and virtual memory T cells. The single unifying theme for all memory T cell subtypes is that they are long-lived and can quickly expand to large numbers of effector T cells upon re-exposure to their cognate antigen. By this mechanism they provide the immune system with ""memory"" against previously encountered pathogens. Memory T cells may be either CD4+ or CD8+ and usually express CD45RO."
  8. SCIENCE|natural and applied sciences|life sciences|biology · SOCIAL QUESTIONS|health|medical science|immunology

    #620209

    IATE #1128334
    T-chill chuimhne Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    memory T lymphocyte | memory T cell
    en
    Sainmhíniú "antigen-specific T cell that persists long-term after an infection has resolved and which expands quickly to large numbers of effector T cells upon re-exposure to their cognate antigen, thus providing a rapid response to past infection" Tagairt "COM-Terminology Coordination, based on: Bryan Tungland. 'Chapter 4 - Role of Gut Microbiota in Immune Homeostasis' (20.10.2021). In: Human Microbiota in Health and Disease From Pathogenesis to Therapy 2018, Pages 135-154"
    Nóta Memory T cells are either CD4+ or the virus-specific CD8+ depending on the type of antigen encountered (MacLeod et al., 2010). The memory T cells include subtypes, central memory T cells (Tcm cells), effector memory T cells (Tem cells and Temra cells) (Willinger et al., 2005), as subtypes. They also typically express CD45RO cell surface protein (Valentine et al., 2013, Akbar et al., 1988).
    lymphocyte T mémoire
    fr
    Sainmhíniú lymphocyte T chargé de conserver le souvenir des protéines déjà rencontrées Tagairt Pour la Science,novembre 1993
  9. SOCIAL QUESTIONS|health|medical science

    #628266

    IATE #1431797
    limficít T scriostóra Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Killer-T-Lymphozyt
    de
    killer T lymphocyte | natural killer T cell | NKT cell
    en
    Sainmhíniú "type of T lymphocyte1 that bridges the adaptive immune system2 with the innate immune system3 and which, unlike conventional T cells that recognise peptide antigens presented by major histocompatibility complex (MHC) molecules, recognises glycolipid antigen presented by a molecule called CD1d1 T lymphocyte [ IATE:1431862 ] 2 adaptive immune system [ IATE:1128235 ]3 innate immune system [ IATE:1128234 ]" Tagairt "COM-Terminology Coordination, based on:Wikipedia. T cell, http://en.wikipedia.org/wiki/T_cell#Natural_killer [14.10.2014]"
    Nóta "Not to be confused with:- natural killer cell [ IATE:1186855 ]"
    lymphocyte T tueur
    fr
  11. SOCIAL QUESTIONS|health|medical science

    #628252

    IATE #1431340
    T-chill sochta Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-limficít sochta Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-Supressor Lymphozyt | Suppressorzellen | T-Suppressorzelle | Suppressor-T-Lymphozyten
    de
    regulatory T cell | Treg | suppressor T lymphocyte | T suppressor lymphocyte | suppressor T cell | T-suppressor cell | Tregs
    en
    Sainmhíniú "T cell whose major role is to shut down T cell-mediated immunity [ IATE:1528623 ] toward the end of an immune reaction and to suppress auto-reactive T cells that escaped the process of negative selection in the thymus" Tagairt "Wikipedia > T cell (23.3.2021)"
    Nóta "They are crucial for the maintenance of immunological tolerance.Two major classes of CD4+ Treg cells have been described — Foxp3+ Treg cells and Foxp3- Treg cells.Regulatory T cells can develop either during normal development in the thymus, and are then known as thymic Treg cells, or can be induced peripherally and are called peripherally derived Tregs. These two subsets were previously called ""naturally occurring"", and ""adaptive"" or ""induced"", respectively."
    lymphocyte T supresseur | lymphocytes T-suppresseurs | T suppressif | lymphocyte T cytotoxique | lymphocyte T suppresseur
    fr
  12. SOCIAL QUESTIONS|health|medical science

    #628271

    IATE #1431862
    T-cill Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-limficít Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    limficít thímeasdíorthaithe Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T-Lymphozyt | T-Lymphocyten | T-Zelle
    de
    T lymphocyte | T-lymphocyte | T-lymphocytes | T cell | T-cell | thymus-dependent lymphocyte | thymus-derived cell | thymus-derived lymphocyte
    en
    Sainmhíniú "lymphocyte which matures in the thymus and and is involved in cell-mediated immunity11 cell-mediated immunity [ IATE:1528623 ]" Tagairt "COM-Terminology Coordination, based on:Patrick Fisher. Immunology Module. Glossary of terms, http://missinglink.ucsf.edu/lm/immunology_module/prologue/glossary.html [14.10.2014]"
    Nóta "This definition excludes regulatory T cells1, which are involved in dampening the adaptive immune response2. T-cells do not produce antibodies3, by contrast with B-cells4. Instead, T-lymphocytes directly attack specific invaders and are thus said to provide cell-mediated immunity. T-cells also play a major role in regulating the function of B-cells.1 regulatory T cell [ IATE:1431340 ]2 adaptive immune response [ IATE:1431364 ]3 antibody [ IATE:1073776 ]4 B-cell [ IATE:1431861 ]"
    lymphocyte T | LT | lymphocyte thymodépendant
    fr
    Sainmhíniú lymphocyte issu du thymus, impliqué tout particulièrement dans la réponse immunitaire de type cellulaire, lors de l'infection par le VIH ; Tout comme les lymphocytes B, les lymphocytes T naissent dans la moëlle osseuse mais maturent de manière différente des lymphocytes B grâce à l'intervention du thymus. Ils sont responsables de l' immunité à médiation cellulaire, c'est-à-dire l' hypersensibilité retardée. Ils jouent un rôle dans l' immunité humorale soit en l'amplifiant (lymphocytes T auxiliaires), soit en l'atténuant avant qu'elle ne devienne excessive (lymphocytes T suppresseurs). Ils peuvent être divisés en 4 groupes fonctionnels distincts: lymphocytes T cytotoxiques, lymphocytes T inducteurs, lymphocytes T auxiliaires, lymphocytes T suppresseurs Tagairt W.Rozembaum,Immunologie,Les dossiers du praticien n° 62,Sida:guide pratique 1990,page 31 ;
    Nóta T inducteurs et T auxiliaires appartiennent au groupe des lymphocytes T4 ou CD4, T cytotoxiques et T suppresseurs appartiennent au groupe des lymphocytes T8 ou CD8.
  13. SOCIAL QUESTIONS|health|illness|cancer · SOCIAL QUESTIONS|health|pharmaceutical industry

    #689647

    IATE #3644649
    greamaire T-cheall Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    T cell engager
    en
    Sainmhíniú antibody designed to bind to a target antigen expressed on a cancer cell and to a trigger molecule on T cells Tagairt "COM-Terminology Coordination, based on: Mark Cobbold. 'Redirecting the immune system’s T cells to eliminate cancer' (2.5.2024). AstraZeneca"
    Nóta These therapeutic molecules then engage T cells that are present in tumours but not capable of recognising cancer cells, redirecting their activity toward the tumour.
  15. SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer

    #690562

    IATE #3648370
    teiripe T-cheall TCR-mhodhnaithe Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    TCR-engineered T cell therapy
    en
    Sainmhíniú "cell therapy using T cells expressing a modified (engineered) T cell receptor directed against a tumour antigen" Tagairt "COM-Terminology Coordination, based on: Baulu E, Gardet C, Chuvin N, Depil S. 'TCR-engineered T cell therapy in solid tumors: State of the art and perspectives' (20.11.2024). Science Advances 2023 Feb 15;9(7):eadf3700. doi: 10.1126/sciadv.adf3700. Epub 2023 Feb 15. PMID: 36791198; PMCID: PMC9931212."
  16. SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer · PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #689692

    IATE #3644712
    cill GTC-T Tagairt Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    TCR-T cell
    en
    Sainmhíniú "T cell expressing an engineered T cell receptor" Tagairt "Baulu E, Gardet C, Chuvin N, Depil S. 'TCR-engineered T cell therapy in solid tumors: State of the art and perspectives' (3.5.2024). Science Advances 2023 Feb 15;9(7):eadf3700. doi: 10.1126/sciadv.adf3700. Epub 2023 Feb 15. PMID: 36791198; PMCID: PMC9931212."