SOCIAL QUESTIONS|health|illness|cancer
- neodraipéine fhaighte Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- leoicéime limficíteach ainsealach T-cheall Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
16 results
- SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer
- imdhíon-teiripe T-cheall uchtaíoch Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- adoptive T cell immunotherapy
- en
- Definition "type of immunotherapy in which T cells are given to a patient to help the body fight diseases, such as cancer" Reference "COM-Terminology Coordination, based on: 'adoptive cell therapy' (20.11.2024). NCI Dictionary of Cancer Terms. National Cancer Institute. US National Institutes of Health "
- SOCIAL QUESTIONS|health|medical science
- cill T4 limficíte Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T4 cell | CD4 T-lymphocyte | CD4 T cell | CD4+ | CD4 lymphocyte | CD4+ T4 lymphocyte | T4 helper | CD4+ T4 helper | helper lymphocyte | helper cell | T-helper cell | helper T-cell | helper T lymphocyte | helper CD4 cell | inducer T-lymphocyte | helper-inducer T-cell | inducer cell
- en
- Definition "T cell 1 bearing on its surface the glycoprotein CD4 (cluster of differentiation 4), and functions by inducing the nearby cell to differentiate, as in triggering precursor T cells to differentiate into mature T cells 1 T cell [ IATE:1431862 ]" Reference "COM-Terminology Coordination, based on: ""Helper-inducer T cell"". Biology Online, http://www.biology-online.org/dictionary/Helper-inducer_T_cell [14.10.2014]"
- Comment The T in T cell stands for thymus. The thymus is the bodily organ where T cells mature. This type of T cell is severely decreased in number in patients suffering from AIDS.
- lymphocyte T auxiliaire | lymphocyte auxiliaire | T facilitant | lymphocyte CD4 | helpers | lymphocyte T4 | lymphocytes T amplificateurs | cellule CD4 | cellule T4 | lymphocyte T helper | CD4 | lymphocyte T inducteur
- fr
- Definition lymphocyte appartenant à une sous-population de lymphocytes issus du thymus, principale cible du virus du VIH, qui porte à sa surface une protéine appelée CD4(anciennement T4) ; Variété de lymphocytes dont l'action est complémentaire à celle des lymphocytes B pour la production d'anticorps et à celle d'autres lymphocytes T dans l'immunité à médiation cellulaire. ; lymphocyte qui déclenche la maturation des lymphocytes T:il provoque la transformation des précurseurs en cellules fonctionnellement distinctes Reference SEC:Rozembaum,W.,Immunologie,Les dossiers du praticien n° 62,Sida:guide pratique 1990,p.31 ; ; N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991
- Comment Les lymphocytes T auxiliaires sécrètent deux facteurs: l' interleukine 2 et l' interféron gamma. Le VIH a un tropisme pour les lymphocytes T auxiliaires car ils possèdent la molécule CD4. L'une des manifestations biologiques du SIDA est donc la disparition des lymphocytes auxiliaires chez le malade. ;
- SOCIAL QUESTIONS|health|medical science
- limficít chíteatocsaineach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- zytotoxische Zelle | Zytotoxischer T-Lymphozyt | zytotoxische T-Zelle
- de
- Definition Immunkompetente Zelle, die ohne Komplement über direkten Kontakt zur Zytolyse bestimmter Zielzellen führen. Reference RL p.1872
- T8 lymphocyte | T8 cell | CD8 cell | CD8 T lymphocyte | CD8 lymphocyte | CD8+ T cell | CD8+ cell | cytotoxic T cell | cytotoxic T lymphocyte
- en
- Definition "type of T cell1 that expresses CD8 (cluster of differentiation 8) transmembrane glycoprotein, and functions by inhibiting, suppressing, or helping to stop an immune response by releasing signals to other immune cells1 T cell [ IATE:1431862 ]" Reference "COM-Terminology Coordination, based on:""Suppressor T cell"". Biology Online, http://www.biology-online.org/dictionary/Suppressor_T_cell [14.10.2014]"
- lymphocyte T8 | lymphocyte cytotoxique | CTL | cellule CD8 | lymphocyte T cytotoxique | cellule T lytique | cellule OKT8 | cellule T8 | lymphocyte CD8 | lymphocyte OKT8
- fr
- Definition lymphocyte T8:lymphocyte T présentant la molécule CD8 à sa surface. Cette classe de globules blancs comprend les lymphocytes T cytotoxiques et les lymphocytes T suppresseurs, et joue un rôle prépondérant dans la régulation du système immunitaire ; seule espèce de lymphocytes T capable de défendre l'organisme de façon active Reference N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991 ; N.Leroy:A terminology of AIDS,FR-EN-ES,Terminologie & traduction 2/1991
- PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology · SOCIAL QUESTIONS|health|pharmaceutical industry · SOCIAL QUESTIONS|health|illness|cancer
- T-chill gabhdóra chiméaraigh aintaiginí Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- chimeric antigen receptor T cell | CAR T cell | CAR-T cell
- en
- Definition "T-lymphocyte which is genetically modified by adding a gene expressing a special receptor (called a chimeric antigen receptor) through which it is targeted against surface components of tumour cells in order to kill those cells" Reference "COM-Terminology Coordination, based on:Kieran Breen. 'Chimeric antigen receptor (CAR) T cell therapies' (30.4.2024). European Medicines Agency (EMA)"
- SOCIAL QUESTIONS|health|medical science
- teiripe T-cheall le gabhdóir ciméarach aintaiginí Reference "Faofa ag an gCoiste Téarmaíochta, www.tearma.ie ;Faomhadh an téarma seo mar chuid de Thionscadal Lex"
- ga
- chimeric antigen receptor T cell therapy | CAR T cell therapy | CAR-T cell therapy | CAR-Tcell therapy
- en
- Definition "type of treatment with CAR T-cells derived from a patient’s own blood (autologous) or derived from a healthy person (allogenic) which are grown in large numbers in the laboratory and then given to the patient by infusion" Reference "COM-Terminology Coordination, based on:Kieran Breen, Chimeric antigen receptor (CAR) T cell therapies (1.2.2021), European Medicines Agency (EMA)"
- Comment Memorial Sloan Kettering Cancer Center (MSK) announced on 14.9.2023 that Michel Sadelain, MD, PhD, renowned physician-scientist, Director of the Center for Cell Engineering, and Stephen and Barbara Friedman Chair, has been awarded the 2024 Breakthrough Prize in Life Sciences. The prestigious prize recognizes Dr. Sadelain and Carl June, MD, of the University of Pennsylvania, for the development of chimeric antigen receptor T cell immunotherapy (CAR T cell therapy) whereby the patient’s T cells are modified to target and kill cancer cells. Dr. Sadelain is a pioneer and leader in the field of immunology, genetic engineering, and the development of CAR T cell therapy. A type of immunotherapy, CAR T cell therapy uses genetically engineered versions of a person’s own immune cells to find and fight cancer.
- SOCIAL QUESTIONS|health|medical science|immunology
- T-chill éifeachtóra Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- effector T cell
- en
- Definition "T cell with limited life span involved in adaptive immunity that has differentiated further after exposure to an antigen and provides the immune system with ""memory"" against previously encountered pathogens" Reference "COM-Terminology Coordination, based on:- ASTRO. 'T Cell Activation and Effector Functions' (3.5.2024)- PluriSelect. 'Effector T cells' (3.5.2024)- Wikipedia > T cell (3.5.2024)"
- Comment "Antigen-naive T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen within the context of an MHC molecule on the surface of a professional antigen presenting cell (e.g. a dendritic cell). Appropriate co-stimulation must be present at the time of antigen encounter for this process to occur. Historically, memory T cells were thought to belong to either the effector or central memory subtypes, each with their own distinguishing set of cell surface markers (see below).[19] Subsequently, numerous new populations of memory T cells were discovered including tissue-resident memory T (Trm) cells, stem memory TSCM cells, and virtual memory T cells. The single unifying theme for all memory T cell subtypes is that they are long-lived and can quickly expand to large numbers of effector T cells upon re-exposure to their cognate antigen. By this mechanism they provide the immune system with ""memory"" against previously encountered pathogens. Memory T cells may be either CD4+ or CD8+ and usually express CD45RO."
- SCIENCE|natural and applied sciences|life sciences|biology · SOCIAL QUESTIONS|health|medical science|immunology
- T-chill chuimhne Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- memory T lymphocyte | memory T cell
- en
- Definition "antigen-specific T cell that persists long-term after an infection has resolved and which expands quickly to large numbers of effector T cells upon re-exposure to their cognate antigen, thus providing a rapid response to past infection" Reference "COM-Terminology Coordination, based on: Bryan Tungland. 'Chapter 4 - Role of Gut Microbiota in Immune Homeostasis' (20.10.2021). In: Human Microbiota in Health and Disease From Pathogenesis to Therapy 2018, Pages 135-154"
- Comment Memory T cells are either CD4+ or the virus-specific CD8+ depending on the type of antigen encountered (MacLeod et al., 2010). The memory T cells include subtypes, central memory T cells (Tcm cells), effector memory T cells (Tem cells and Temra cells) (Willinger et al., 2005), as subtypes. They also typically express CD45RO cell surface protein (Valentine et al., 2013, Akbar et al., 1988).
- lymphocyte T mémoire
- fr
- Definition lymphocyte T chargé de conserver le souvenir des protéines déjà rencontrées Reference Pour la Science,novembre 1993
- SOCIAL QUESTIONS|health|medical science
- limficít T scriostóra Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- killer T lymphocyte | natural killer T cell | NKT cell
- en
- Definition "type of T lymphocyte1 that bridges the adaptive immune system2 with the innate immune system3 and which, unlike conventional T cells that recognise peptide antigens presented by major histocompatibility complex (MHC) molecules, recognises glycolipid antigen presented by a molecule called CD1d1 T lymphocyte [ IATE:1431862 ] 2 adaptive immune system [ IATE:1128235 ]3 innate immune system [ IATE:1128234 ]" Reference "COM-Terminology Coordination, based on:Wikipedia. T cell, http://en.wikipedia.org/wiki/T_cell#Natural_killer [14.10.2014]"
- Comment "Not to be confused with:- natural killer cell [ IATE:1186855 ]"
- SOCIAL QUESTIONS|health|illness|cancer
- leoicéime limfeablastach T-cheall réamhtheachtach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- SOCIAL QUESTIONS|health|medical science
- T-chill sochta Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T-limficít sochta Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- regulatory T cell | Treg | suppressor T lymphocyte | T suppressor lymphocyte | suppressor T cell | T-suppressor cell | Tregs
- en
- Definition "T cell whose major role is to shut down T cell-mediated immunity [ IATE:1528623 ] toward the end of an immune reaction and to suppress auto-reactive T cells that escaped the process of negative selection in the thymus" Reference "Wikipedia > T cell (23.3.2021)"
- Comment "They are crucial for the maintenance of immunological tolerance.Two major classes of CD4+ Treg cells have been described — Foxp3+ Treg cells and Foxp3- Treg cells.Regulatory T cells can develop either during normal development in the thymus, and are then known as thymic Treg cells, or can be induced peripherally and are called peripherally derived Tregs. These two subsets were previously called ""naturally occurring"", and ""adaptive"" or ""induced"", respectively."
- SOCIAL QUESTIONS|health|medical science
- T-cill Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T-limficít Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- limficít thímeasdíorthaithe Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T-Lymphozyt | T-Lymphocyten | T-Zelle
- de
- T lymphocyte | T-lymphocyte | T-lymphocytes | T cell | T-cell | thymus-dependent lymphocyte | thymus-derived cell | thymus-derived lymphocyte
- en
- Definition "lymphocyte which matures in the thymus and and is involved in cell-mediated immunity11 cell-mediated immunity [ IATE:1528623 ]" Reference "COM-Terminology Coordination, based on:Patrick Fisher. Immunology Module. Glossary of terms, http://missinglink.ucsf.edu/lm/immunology_module/prologue/glossary.html [14.10.2014]"
- Comment "This definition excludes regulatory T cells1, which are involved in dampening the adaptive immune response2. T-cells do not produce antibodies3, by contrast with B-cells4. Instead, T-lymphocytes directly attack specific invaders and are thus said to provide cell-mediated immunity. T-cells also play a major role in regulating the function of B-cells.1 regulatory T cell [ IATE:1431340 ]2 adaptive immune response [ IATE:1431364 ]3 antibody [ IATE:1073776 ]4 B-cell [ IATE:1431861 ]"
- lymphocyte T | LT | lymphocyte thymodépendant
- fr
- Definition lymphocyte issu du thymus, impliqué tout particulièrement dans la réponse immunitaire de type cellulaire, lors de l'infection par le VIH ; Tout comme les lymphocytes B, les lymphocytes T naissent dans la moëlle osseuse mais maturent de manière différente des lymphocytes B grâce à l'intervention du thymus. Ils sont responsables de l' immunité à médiation cellulaire, c'est-à-dire l' hypersensibilité retardée. Ils jouent un rôle dans l' immunité humorale soit en l'amplifiant (lymphocytes T auxiliaires), soit en l'atténuant avant qu'elle ne devienne excessive (lymphocytes T suppresseurs). Ils peuvent être divisés en 4 groupes fonctionnels distincts: lymphocytes T cytotoxiques, lymphocytes T inducteurs, lymphocytes T auxiliaires, lymphocytes T suppresseurs Reference W.Rozembaum,Immunologie,Les dossiers du praticien n° 62,Sida:guide pratique 1990,page 31 ;
- Comment T inducteurs et T auxiliaires appartiennent au groupe des lymphocytes T4 ou CD4, T cytotoxiques et T suppresseurs appartiennent au groupe des lymphocytes T8 ou CD8.
- SOCIAL QUESTIONS|health|illness|cancer · SOCIAL QUESTIONS|health|pharmaceutical industry
- greamaire T-cheall Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T cell engager
- en
- Definition antibody designed to bind to a target antigen expressed on a cancer cell and to a trigger molecule on T cells Reference "COM-Terminology Coordination, based on: Mark Cobbold. 'Redirecting the immune system’s T cells to eliminate cancer' (2.5.2024). AstraZeneca"
- Comment These therapeutic molecules then engage T cells that are present in tumours but not capable of recognising cancer cells, redirecting their activity toward the tumour.
- SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer
- tnáitheadh T-cheall Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- T-cell exhaustion
- en
- Definition state of T-cell dysfunction arising from persistent activation in response to chronic antigen exposure, such as during chronic viral infections or cancer Reference "Ishita Gupta, Ola Hussein, Konduru Seetharama Sastry, Salim Bougarn, Neha Gopinath, Evonne Chin-Smith, Yashi Sinha, Hesham Mohamed Korashy, Cristina Maccalli. 'Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications' (21.11.2024). Advances in Cancer Biology - Metastasis Volume 8, October 2023, 100107"
- SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer
- teiripe T-cheall TCR-mhodhnaithe Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- TCR-engineered T cell therapy
- en
- Definition "cell therapy using T cells expressing a modified (engineered) T cell receptor directed against a tumour antigen" Reference "COM-Terminology Coordination, based on: Baulu E, Gardet C, Chuvin N, Depil S. 'TCR-engineered T cell therapy in solid tumors: State of the art and perspectives' (20.11.2024). Science Advances 2023 Feb 15;9(7):eadf3700. doi: 10.1126/sciadv.adf3700. Epub 2023 Feb 15. PMID: 36791198; PMCID: PMC9931212."
- SOCIAL QUESTIONS|health|medical science|immunology · SOCIAL QUESTIONS|health|illness|cancer · PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology
- cill GTC-T Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
- ga
- TCR-T cell
- en
- Definition "T cell expressing an engineered T cell receptor" Reference "Baulu E, Gardet C, Chuvin N, Depil S. 'TCR-engineered T cell therapy in solid tumors: State of the art and perspectives' (3.5.2024). Science Advances 2023 Feb 15;9(7):eadf3700. doi: 10.1126/sciadv.adf3700. Epub 2023 Feb 15. PMID: 36791198; PMCID: PMC9931212."