Gaois

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5 results

  1. AGRI-FOODSTUFFS|food technology

    #683591

    IATE #3555527
    géin nár bhain an sprioc amach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    off target gene
    en
    Definition unintended genetic alteration or modification in a cell or organism, caused by a gene-editing technique, which can potentially lead to unforeseen consequences for the organism's phenotype or function Reference "SCIC-CT, based on: genome.gov> genetics-glossary > Search | NHGRI (16.9.2024)"
    gène «non ciblé»
    fr
  2. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664672

    IATE #3592559
    gníomhaíocht neamhsprice Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    off-target activity
    en
    Definition activity of an enzyme at sites different from the target site in the genome due to limited specificity of that enzyme Reference "EFSA Panel on Genetically modified organisms (GMO); 'Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function' (26.1.2021). EFSA Journal 2012;10(10):2943. [31 pp.] doi:10.2903/j.efsa.2012.2943. Available online: www.efsa.europa.eu/efsajournal"
    Comment Used usually for SDN enzymes
  3. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664702

    IATE #3592619
    ionsá neamh-spriocdhírithe Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Context '... is gá ionsánna neamh-spriocdhírithe (a mbíonn, mar shampla, siadaí/ailse, mífheidhmithe meitibileacha ina dtoradh orthu) agus só-ghineas ionlocach agus géineatocsaineacht (ionsá gnéithe géiniteacha agus léiriú próitéiní modhnaithe DNA mar mheáin iompair fo-iarsmaí géineatocsaineacha) sa spriocspeiceas a chur san áireamh...' Reference "Rialachán Tarmligthe (AE) 2021/805 lena leasaítear Iarscríbhinn II a ghabhann le Rialachán (AE) 2019/6 ó Pharlaimint na hEorpa agus ón gComhairle, CELEX:32021R0805/GA"
    ungezielte Insertion
    de
    off-target insertion | untargeted insertion
    en
    Definition insertion of DNA at a different site than the one targeted Reference "COM-Terminology Coordination, based on: Yamamoto Y, Gerbi SA. 'Making ends meet: targeted integration of DNA fragments by genome editing' (1.2.2021). Chromosoma. 2018;127(4):405-420. doi:10.1007/s00412-018-0677-6"
    insertion hors cible
    fr
    Definition insertion d'ADN sur un site autre que le site ciblé Reference COM-FR, d'après COM-Terminology Coordination
  4. SCIENCE|natural and applied sciences|life sciences|pharmacology

    #664723

    IATE #3592681
    trasnaíocht nár bhain amach an sprioc Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Context '... maidir le táirgí teiripe trasnaíochta trí mheán RNA (RNAi), tabharfar aghaidh ar éifeachtaí díobhálacha féideartha na trasnaíochta nár bhain amach an sprioc (i ngeall ar an ribe dhearfach RNAi), mar aon leis an bhféidearthacht go bhféadfaí an bhacainn idir an fhuil agus an inchinn a thrasnú, rud a d’fhéadfadh a bheith ina chúis le neamhoird de chuid lárchóras na néaróg...' Reference "Rialachán Tarmligthe (AE) 2021/805 lena leasaítear Iarscríbhinn II a ghabhann le Rialachán (AE) 2019/6 ó Pharlaimint na hEorpa agus ón gComhairle, CELEX:32021R0805/GA"
    trasnaíocht seachsprice Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Off-Target-Interferenz
    de
    off-target interference
    en
    Definition unwanted interference of a candidate pharmaceutical product with normal biological processes Reference "COM-Terminology Coordination, based on: Ana M. Morenoa, Nathan Palmerb, FernandoAlemánc, Genghao Chena, Andrew Plaa, Wei Leong Chewd, Mansun Lawc, Prashant Mal. 'Exploring protein orthogonality in immune space: a case study with AAVand Cas9 orthologs' (3.2.2021). bioRxiv 245985"
    interférence hors cible
    fr
    Definition interférence non souhaitée d'un candidat médicament avec un processus biologique Reference COM-FR, d'après COM-Terminology Coordination
  5. PRODUCTION, TECHNOLOGY AND RESEARCH|technology and technical regulations|biotechnology

    #664657

    IATE #3592534
    modhnú nár bhain an sprioc amach Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Context 'Maidir le substaintí a bhfuil sé beartaithe iad a chomhtháthú sa ghéanóm nó an géanóm a mhodhnú leo, déanfar tástálacha chun meastóireacht a dhéanamh ar an riosca de mhodhnuithe nár bhain an sprioc amach agus/nó de shó-ghineas ionlocach.' Reference "Rialachán Tarmligthe (AE) 2021/805 lena leasaítear Iarscríbhinn II a ghabhann le Rialachán (AE) 2019/6 ó Pharlaimint na hEorpa agus ón gComhairle, CELEX:32021R0805/GA"
    modhnú seachsprice Reference Faomhadh an téarma seo mar chuid de Thionscadal Lex
    ga
    Off-Target-Veränderung | Off-Target-Effekt
    de
    Definition ungewollte Veränderungen der DNA an Nicht-Zielsequenzen Reference "FGU - Fachstelle Genetik und Umwelt: Hintergrund: CRISPR/Cas (Risiken) (1.6.2021)"
    off-target change | off-target edit | off-target mutation | off-target modification
    en
    Definition unintended, non-specific mutation occurring at a site with sequence similarity to the targeted edit region Reference "Nathaniel Graham, Gunvant B. Patil, David M. Bubeck, Raymond C. Dobert, Kevin C. Glenn, Annie T. Gutsche, Sandeep Kumar, John A. Lindbo, Luis Maas, Gregory D. May, Miguel E. Vega-Sanchez, Robert M. Stupar, Peter L. Morrell. 'Plant Genome Editing and the Relevance of Off-Target Changes' (26.1.2021). Plant Physiology Aug 2020, 183 (4) 1453-1471; DOI: 10.1104/pp.19.01194"
    mutation hors cible | modification hors cible | changement hors cible
    fr
    Definition mutation se produisant en dehors de la zone initialement ciblée par l'édition génomique, sur un site dont la séquence est similaire Reference "COM-FR, d'après:- Inserm - La science pour la santé, Information en santé, Dossiers d'information > Édition génomique (11.3.2021)- Pourquoi docteur - Comprendre pour agir > Question d'actu > Innovation, 5 décembre 2019, «Mutations génétiques : inquiétudes pour les jumelles «CRISPR» en Chine» (11.3.2021)"